Magnesium in PDB 6mxd: Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp

The structure of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp, PDB code: 6mxd was solved by D.Teran, L.Guddat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.27 / 2.96
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	59.285, 64.984, 79.075, 85.74, 74.58, 62.87
R / Rfree (%)	25.2 / 30.2

The binding sites of Magnesium atom in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp (pdb code 6mxd). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp, PDB code: 6mxd:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:26.8 occ:1.00 O A:HOH402 2.1 26.3 1.0 O A:HOH401 2.1 28.8 1.0 N A:LYS87 3.5 27.2 1.0 N A:GLY88 3.6 47.8 1.0 NH1 A:ARG214 3.6 33.0 1.0 O2' A:IMP301 4.0 47.7 1.0 CA A:GLY88 4.1 47.2 1.0 NH2 A:ARG214 4.1 35.1 1.0 C A:LYS87 4.2 50.6 1.0 CA A:LYS87 4.2 55.9 1.0 CZ A:ARG214 4.3 33.4 1.0 CB A:LYS87 4.3 27.7 1.0 C A:LEU86 4.4 26.8 1.0 O A:LEU86 4.4 27.3 1.0 OD2 A:ASP148 4.6 46.7 1.0 CG A:GLU208 4.8 45.4 1.0

Magnesium binding site 2 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg3302 b:33.8 occ:1.00 O B:HOH3405 2.4 13.2 1.0 NH2 B:ARG214 3.6 52.6 1.0 N B:LYS87 3.7 28.9 1.0 N B:GLY88 4.1 29.8 1.0 CB B:LYS87 4.3 27.8 1.0 CA B:LYS87 4.4 27.6 1.0 O B:LEU86 4.5 30.0 1.0 O2' B:IMP3301 4.5 50.3 1.0 C B:LEU86 4.5 30.1 1.0 C B:LYS87 4.8 27.7 1.0 CZ B:ARG214 4.8 51.5 1.0 CA B:GLY88 5.0 30.2 1.0 OD1 B:ASP148 5.0 72.0 1.0

Magnesium binding site 3 out of 3 in the Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of Trypanosoma Brucei Hypoxanthine-Guanine-Xanthine Phosphoribosyltranferase in Complex with Imp within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg302 b:48.1 occ:1.00 NH2 C:ARG214 3.2 37.6 1.0 N C:LYS87 3.5 47.0 1.0 CB C:LYS87 3.7 47.7 1.0 CG C:LYS87 4.0 42.7 1.0 CA C:LYS87 4.1 49.8 1.0 CZ C:ARG214 4.1 35.9 1.0 OE2 C:GLU208 4.2 50.9 1.0 NH1 C:ARG214 4.2 33.5 1.0 N C:GLY88 4.3 57.4 1.0 C C:LYS87 4.6 57.1 1.0 C C:LEU86 4.6 43.5 1.0 O C:LEU86 4.7 42.0 1.0 CD C:GLU208 4.8 49.1 1.0

D.Teran, E.Dolezelova, D.T.Keough, D.Hockova, A.Zikova, L.W.Guddat. Crystal Structures of Trypanosoma Brucei Hypoxanthine - Guanine - Xanthine Phosphoribosyltransferase in Complex with Imp, Gmp and Xmp. Febs J. 2019.
ISSN: ISSN 1742-464X
PubMed: 31287615
DOI: 10.1111/FEBS.14987