Magnesium in PDB 6uy0: Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions

All present enzymatic activity of Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions:
7.6.2.2; 7.6.2.3;

The binding sites of Magnesium atom in the Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions (pdb code 6uy0). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions, PDB code: 6uy0:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1603 b:0.2 occ:1.00 OG A:SER685 1.9 1.0 1.0 O1G A:ATP1601 1.9 0.5 1.0 O1B A:ATP1601 2.0 0.8 1.0 OE1 A:GLN713 2.1 0.8 1.0 CD A:GLN713 3.0 0.3 1.0 CB A:SER685 3.1 0.3 1.0 PG A:ATP1601 3.2 0.4 1.0 PB A:ATP1601 3.2 0.9 1.0 NE2 A:GLN713 3.4 0.4 1.0 O3B A:ATP1601 3.5 0.1 1.0 N A:SER685 4.0 0.2 1.0 OD1 A:ASP792 4.0 0.9 1.0 CA A:SER685 4.1 0.7 1.0 O2G A:ATP1601 4.2 0.6 1.0 O3G A:ATP1601 4.2 0.8 1.0 O2B A:ATP1601 4.2 0.8 1.0 O3A A:ATP1601 4.4 0.3 1.0 CG A:GLN713 4.4 0.7 1.0 OD2 A:ASP792 4.5 0.7 1.0 O2A A:ATP1601 4.6 0.3 1.0 CG A:ASP792 4.7 0.3 1.0 CB A:GLN713 4.8 0.6 1.0 O1A A:ATP1601 4.8 0.1 1.0 PA A:ATP1601 4.9 0.7 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of Wild-Type Bovine Multidrug Resistance Protein 1 (MRP1) Under Active Turnover Conditions within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1604 b:0.7 occ:1.00 OG A:SER1333 1.9 0.6 1.0 O2B A:ADP1602 2.0 0.9 1.0 OE1 A:GLN1374 2.4 0.5 1.0 CB A:SER1333 3.1 0.0 1.0 CD A:GLN1374 3.3 0.8 1.0 PB A:ADP1602 3.4 0.1 1.0 NE2 A:GLN1374 3.6 0.8 1.0 O1B A:ADP1602 3.9 0.1 1.0 OD1 A:ASP1453 4.1 0.3 1.0 O3A A:ADP1602 4.1 0.7 1.0 CA A:SER1333 4.1 0.9 1.0 N A:SER1333 4.1 0.8 1.0 OE2 A:GLU1454 4.3 0.1 1.0 O3B A:ADP1602 4.5 0.5 1.0 O2A A:ADP1602 4.6 0.9 1.0 OD2 A:ASP1453 4.7 0.3 1.0 CG A:GLN1374 4.7 0.1 1.0 CG A:ASP1453 4.8 0.6 1.0 PA A:ADP1602 4.9 0.1 1.0 CD A:GLU1454 4.9 0.1 1.0

L.Wang, Z.L.Johnson, M.R.Wasserman, J.Levring, J.Chen, S.Liu. Characterization of the Kinetic Cycle of An Abc Transporter By Single-Molecule and Cryo-Em Analyses. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32458799
DOI: 10.7554/ELIFE.56451