Magnesium in PDB 6xbx: Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp

All present enzymatic activity of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp:
2.7.11.17;

The structure of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp, PDB code: 6xbx was solved by C.Ozden, J.C.Foster, M.M.Stratton, S.C.Garman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.56 / 2.56
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	73.143, 91.423, 91.922, 90.00, 90.00, 90.00
R / Rfree (%)	20.3 / 28.8

The binding sites of Magnesium atom in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp (pdb code 6xbx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp, PDB code: 6xbx:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:42.5 occ:1.00 O2B A:ATP301 2.0 85.5 1.0 OD1 A:ASN140 2.1 29.0 1.0 OD2 A:ASP156 2.9 29.0 1.0 CG A:ASN140 3.2 30.5 1.0 O3G A:ATP301 3.3 60.4 1.0 O A:GLU139 3.4 35.4 1.0 PB A:ATP301 3.4 71.3 1.0 C A:GLU139 3.8 31.2 1.0 O3A A:ATP301 4.0 68.1 1.0 CA A:ASN140 4.0 28.4 1.0 N A:ASN140 4.0 31.4 1.0 O3B A:ATP301 4.0 75.5 1.0 O2A A:ATP301 4.1 98.3 1.0 CG A:ASP156 4.1 29.7 1.0 ND2 A:ASN140 4.1 28.8 1.0 CB A:ASN140 4.2 29.0 1.0 PG A:ATP301 4.2 70.0 1.0 CB A:GLU139 4.3 30.6 1.0 C5' A:ATP301 4.3 62.7 1.0 C3' A:ATP301 4.4 51.4 1.0 OE1 A:GLU96 4.4 40.1 1.0 CB A:ASP156 4.5 26.8 1.0 O1B A:ATP301 4.5 68.8 1.0 C2' A:ATP301 4.6 47.9 1.0 PA A:ATP301 4.6 89.2 1.0 CA A:GLU139 4.7 31.1 1.0 CE A:LYS137 4.8 26.7 1.0 O1G A:ATP301 4.8 43.0 1.0 O5' A:ATP301 4.9 81.2 1.0 C4' A:ATP301 5.0 57.4 1.0

Magnesium binding site 2 out of 2 in the Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg302 b:43.6 occ:1.00 OD1 B:ASN140 2.6 28.3 1.0 O5' B:ATP301 2.7 63.8 1.0 O2B B:ATP301 2.7 59.3 1.0 O B:GLU139 3.3 29.2 1.0 C5' B:ATP301 3.3 58.7 1.0 O3A B:ATP301 3.6 58.6 1.0 C3' B:ATP301 3.7 48.0 1.0 C2' B:ATP301 3.7 43.1 1.0 CG B:ASN140 3.7 26.6 1.0 PB B:ATP301 3.8 71.2 1.0 PA B:ATP301 3.8 59.8 1.0 CB B:ASP156 3.9 34.6 1.0 C4' B:ATP301 4.0 54.3 1.0 O2A B:ATP301 4.2 55.0 1.0 C B:GLU139 4.2 28.9 1.0 CA B:ASN140 4.3 24.1 1.0 OE1 B:GLU96 4.3 31.1 1.0 O2' B:ATP301 4.4 40.5 1.0 OD2 B:ASP156 4.5 57.4 1.0 CB B:ASN140 4.6 24.2 1.0 ND2 B:ASN140 4.7 25.7 1.0 CG B:ASP156 4.7 41.9 1.0 N B:ASN140 4.7 25.1 1.0 O1B B:ATP301 4.7 64.9 1.0 O4' B:ATP301 4.8 47.0 1.0 N B:ASP156 4.9 28.6 1.0 C1' B:ATP301 4.9 41.2 1.0 O3' B:ATP301 5.0 48.6 1.0 O3B B:ATP301 5.0 63.4 1.0

C.Ozden, M.M.Stratton, S.C.Garman. Cocrystal Structure of Human Camkii-Alpha (CAMK2A)Kinase Domain and GLUN2B in Complex with Atp To Be Published.