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Magnesium in PDB 7fs7: Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
All present enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20:
2.7.1.40;
2.7.1.40;
Protein crystallography data
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20, PDB code: 7fs7
was solved by
A.Lulla,
O.Nilsson,
P.Brear,
A.Nain-Perez,
M.Grotli,
M.Hyvonen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 187.06 / 2.77 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 206.019, 113.177, 187.302, 90, 92.9, 90 |
| R / Rfree (%) | 25.1 / 30.1 |
Other elements in 7fs7:
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 also contains other interesting chemical elements:
| Potassium | (K) | 8 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
(pdb code 7fs7). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 8 binding sites of Magnesium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20, PDB code: 7fs7:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Magnesium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20, PDB code: 7fs7:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Magnesium binding site 1 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 1 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 2 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 2 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 3 out of 8 in 7fs7
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Magnesium Binding Sites List in 7fs7
Magnesium binding site 3 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 4 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 4 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 4 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 5 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 5 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 5 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 6 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 6 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 6 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 7 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 7 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 7 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Magnesium binding site 8 out of 8 in 7fs7
Go back to
Magnesium Binding Sites List in 7fs7
Magnesium binding site 8 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 8 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 20 within 5.0Å range:
|
Reference:
A.Nain-Perez,
O.Nilsson,
A.Lulla,
L.Haversen,
P.Brear,
S.Liljenberg,
M.Hyvonen,
J.Boren,
M.Grotli.
Tuning Liver Pyruvate Kinase Activity Up or Down with A New Class of Allosteric Modulators. Eur.J.Med.Chem. V. 250 15177 2023.
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
Page generated: Wed Oct 2 21:45:31 2024
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
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