Magnesium in PDB 7k1i: Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063

Enzymatic activity of Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063

All present enzymatic activity of Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063:
2.7.10.1;

Protein crystallography data

The structure of Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063, PDB code: 7k1i was solved by T.S.Beyett, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 53.94 / 3.20
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 148.03, 35.8, 54.8, 90, 100.19, 90
R / Rfree (%) 26.3 / 31.1

Other elements in 7k1i:

The structure of Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063 also contains other interesting chemical elements:

Fluorine (F) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063 (pdb code 7k1i). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063, PDB code: 7k1i:

Magnesium binding site 1 out of 1 in 7k1i

Go back to Magnesium Binding Sites List in 7k1i
Magnesium binding site 1 out of 1 in the Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09- 063 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1101

b:68.3
occ:1.00
 O2A A:ANP1102 1.8 167.3 1.0
O1B A:ANP1102 1.9 161.8 1.0
O2G A:ANP1102 2.1 161.3 1.0
OD2 A:ASP855 2.1 139.7 1.0
OD1 A:ASN842 2.3 122.9 1.0
PA A:ANP1102 3.1 163.8 1.0
PB A:ANP1102 3.2 160.4 1.0
CG A:ASP855 3.3 134.4 1.0
CG A:ASN842 3.5 118.7 1.0
O3A A:ANP1102 3.5 165.5 1.0
PG A:ANP1102 3.6 154.1 1.0
O5' A:ANP1102 3.6 148.9 1.0
NZ A:LYS745 4.0 111.6 1.0
N3B A:ANP1102 4.0 159.9 1.0
CB A:ASP855 4.1 129.3 1.0
ND2 A:ASN842 4.2 121.9 1.0
OD1 A:ASP855 4.3 131.4 1.0
O1A A:ANP1102 4.3 170.1 1.0
O2B A:ANP1102 4.3 162.2 1.0
NH2 A:ARG858 4.4 162.8 1.0
O A:ARG841 4.4 121.0 1.0
O1G A:ANP1102 4.4 155.0 1.0
O3G A:ANP1102 4.5 151.2 1.0
CB A:ASN842 4.6 113.7 1.0
CA A:ASN842 4.6 114.2 1.0
CG2 A:THR854 4.6 96.6 1.0
C8 A:ANP1102 4.6 102.8 1.0
C2' A:ANP1102 4.9 120.5 1.0
C A:ARG841 4.9 123.8 1.0

Reference:

T.S.Beyett, C.To, D.E.Heppner, J.Jang, B.H.Shin, G.Gomez, P.A.Janne, N.S.Gray, M.J.Eck. Egfr Kinase (L858R/V948R) in Complex with Allosteric Inhibitor Jbj-09-063 To Be Published.
Page generated: Fri Sep 24 15:17:44 2021

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy