Magnesium in PDB 7m0z: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766:
2.7.11.1; 2.7.12.2;

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766, PDB code: 7m0z was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.33 / 3.12
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	116.784, 116.784, 129.256, 90, 90, 120
R / Rfree (%)	19.1 / 22.5

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Magnesium atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 (pdb code 7m0z). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766, PDB code: 7m0z:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:73.8 occ:1.00 O1B A:ANP801 2.1 69.8 1.0 OD1 A:ASN581 2.3 79.5 1.0 OD2 A:ASP594 2.4 82.0 1.0 O1A A:ANP801 2.6 81.6 1.0 O2G A:ANP801 3.0 75.6 1.0 CG A:ASN581 3.4 73.7 1.0 O A:ASN580 3.4 76.9 1.0 PB A:ANP801 3.6 71.7 1.0 CG A:ASP594 3.6 85.0 1.0 PA A:ANP801 3.7 83.5 1.0 C8 A:ANP801 3.8 84.3 1.0 CA A:ASN581 3.9 71.5 1.0 O5' A:ANP801 3.9 84.0 1.0 C A:ASN580 4.0 70.2 1.0 O3A A:ANP801 4.1 87.9 1.0 CB A:ASN581 4.1 65.4 1.0 N7 A:ANP801 4.2 85.5 1.0 N A:ASN581 4.2 68.0 1.0 PG A:ANP801 4.4 83.8 1.0 O2B A:ANP801 4.4 71.6 1.0 ND2 A:ASN581 4.4 79.1 1.0 CE1 A:PHE583 4.4 79.8 1.0 OD1 A:ASP594 4.5 88.1 1.0 CZ A:PHE583 4.5 86.5 1.0 CB A:ASP594 4.5 72.2 1.0 N3B A:ANP801 4.5 81.6 1.0 C2' A:ANP801 4.7 81.8 1.0 N9 A:ANP801 4.8 87.4 1.0 CB A:ASN580 4.9 70.6 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg403 b:111.3 occ:1.00 O2B B:ANP401 2.0 107.2 0.8 OD1 B:ASN195 2.4 80.0 1.0 OD2 B:ASP208 2.4 105.3 1.0 O2A B:ANP401 2.6 110.8 0.8 CG B:ASP208 3.5 98.5 1.0 CG B:ASN195 3.6 75.8 1.0 PB B:ANP401 3.6 122.5 0.8 O B:SER194 3.7 84.1 1.0 O3G B:ANP401 3.7 112.4 0.8 PA B:ANP401 3.9 107.5 0.8 NZ B:LYS97 4.0 110.1 1.0 CB B:ASP208 4.0 83.8 1.0 ND2 B:ASN195 4.3 74.9 1.0 C B:SER194 4.3 69.7 1.0 O3A B:ANP401 4.3 124.8 0.8 O1B B:ANP401 4.3 107.0 0.8 O5' B:ANP401 4.5 102.6 0.8 OG B:SER194 4.5 89.0 1.0 OD1 B:ASP208 4.5 103.3 1.0 CB B:SER194 4.6 81.7 1.0 CA B:ASN195 4.6 73.8 1.0 N3B B:ANP401 4.7 114.7 0.8 CB B:ASN195 4.7 75.1 1.0 N B:ASN195 4.7 70.8 1.0 CE B:LYS192 4.7 83.5 1.0 PG B:ANP401 4.8 127.4 0.8

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 To Be Published.