Magnesium in PDB 7mcr: Human Apex/REF1 Homodimer Formed Under Oxidative Condition

The structure of Human Apex/REF1 Homodimer Formed Under Oxidative Condition, PDB code: 7mcr was solved by Y.W.Nam, S.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.84 / 1.90
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	77.042, 44.794, 77.436, 90, 92.27, 90
R / Rfree (%)	16.3 / 23.3

The binding sites of Magnesium atom in the Human Apex/REF1 Homodimer Formed Under Oxidative Condition (pdb code 7mcr). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Apex/REF1 Homodimer Formed Under Oxidative Condition, PDB code: 7mcr:

Magnesium binding site 1 out of 1 in the Human Apex/REF1 Homodimer Formed Under Oxidative Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Apex/REF1 Homodimer Formed Under Oxidative Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg401 b:20.1 occ:0.00 OE1 A:GLU96 1.9 24.4 1.0 O A:HOH516 2.1 24.1 1.0 OD1 A:ASP70 2.3 16.6 1.0 O A:HOH646 2.3 24.7 1.0 O A:HOH564 2.4 20.0 1.0 O A:HOH567 2.5 11.7 1.0 CD A:GLU96 2.9 17.0 1.0 CG A:ASP70 3.2 17.6 1.0 OE2 A:GLU96 3.3 23.1 1.0 OD2 A:ASP70 4.0 16.3 1.0 CB A:ASP70 4.1 9.4 1.0 OD2 A:ASP308 4.1 16.8 1.0 O A:HOH598 4.2 13.3 1.0 CG A:GLU96 4.3 26.0 1.0 NZ A:LYS98 4.4 21.2 1.0 OD1 A:ASP308 4.4 12.5 1.0 O A:HOH801 4.4 30.0 1.0 CA A:ASP70 4.5 14.3 1.0 CE A:LYS98 4.7 18.0 1.0 O A:HOH778 4.7 26.5 1.0 O A:HOH798 4.7 31.4 1.0 CG A:ASP308 4.7 16.4 1.0 OD1 A:ASN68 4.9 11.6 1.0

Y.W.Nam, E.B.Khanjani, S.Fong, S.Chawla, S.Rahighi, K.Parang, M.Zhang, S.Yang. The Development of Novel Apurinic/Aprymidinic Endonuclease/Redox-Factor 1 Inhibitors For the Treatment of Human Melanoma To Be Published.