Magnesium in PDB 7nrw: Human Myelin Protein P2 Mutant M114T

The structure of Human Myelin Protein P2 Mutant M114T, PDB code: 7nrw was solved by M.Uusitalo, S.Ruskamo, P.Kursula, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.72 / 2.00
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	64.79, 64.79, 100.93, 90, 90, 90
R / Rfree (%)	20.7 / 25

The structure of Human Myelin Protein P2 Mutant M114T also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Magnesium atom in the Human Myelin Protein P2 Mutant M114T (pdb code 7nrw). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Myelin Protein P2 Mutant M114T, PDB code: 7nrw:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Human Myelin Protein P2 Mutant M114T


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Myelin Protein P2 Mutant M114T within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg203 b:43.3 occ:1.00 OD2 A:ASP19 2.1 57.8 1.0 O A:HOH356 2.2 45.3 1.0 O A:HOH349 2.4 38.2 1.0 OD1 A:ASN16 2.4 36.3 1.0 CG A:ASP19 3.2 51.5 1.0 HB2 A:ASP19 3.3 59.7 1.0 HD22 A:ASN16 3.4 48.2 1.0 CG A:ASN16 3.4 37.7 1.0 CB A:ASP19 3.7 49.7 1.0 ND2 A:ASN16 3.7 40.1 1.0 MG A:MG204 3.8 58.0 1.0 HB3 A:ASP19 3.9 59.7 1.0 O A:HOH344 3.9 40.0 1.0 OD1 A:ASP19 4.3 50.1 1.0 HA A:ASN16 4.5 43.0 1.0 HD21 A:ASN16 4.6 48.2 1.0 CB A:ASN16 4.7 40.7 1.0 H A:ASP19 4.8 41.3 1.0 HB2 A:ASN16 4.9 48.8 1.0

Magnesium binding site 2 out of 2 in the Human Myelin Protein P2 Mutant M114T


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human Myelin Protein P2 Mutant M114T within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg204 b:58.0 occ:1.00 O A:HOH314 2.5 44.3 1.0 O A:HOH356 2.7 45.3 1.0 O A:HOH344 2.7 40.0 1.0 OD2 A:ASP19 2.8 57.8 1.0 CG A:ASP19 3.4 51.5 1.0 OD1 A:ASP19 3.5 50.1 1.0 HB3 A:ASP18 3.7 33.7 1.0 MG A:MG203 3.8 43.3 1.0 O A:HOH368 4.2 48.9 1.0 H A:ASP19 4.3 41.3 1.0 OD1 A:ASN16 4.5 36.3 1.0 HB2 A:ASP19 4.5 59.7 1.0 CB A:ASP19 4.5 49.7 1.0 OD2 A:ASP18 4.6 42.4 1.0 CB A:ASP18 4.7 28.1 1.0 N A:ASP19 4.8 34.4 1.0 O A:HOH358 4.9 37.1 1.0 HZ2 A:LYS22 4.9 72.0 1.0 HA A:ASN16 5.0 43.0 1.0

M.Uusitalo, M.B.Klenow, S.Laulumaa, M.P.Blakeley, A.C.Simonsen, S.Ruskamo, P.Kursula. Human Myelin Protein P2: From Crystallography to Time-Lapse Membrane Imaging and Neuropathy-Associated Variants. Febs J. 2021.
ISSN: ISSN 1742-464X
PubMed: 34138518
DOI: 10.1111/FEBS.16079