Magnesium in PDB 7owy: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site

Enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site:
1.16.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site, PDB code: 7owy was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.57 / 1.55
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 184.111, 184.111, 184.111, 90, 90, 90
R / Rfree (%) 15.3 / 17.2

Other elements in 7owy:

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site also contains other interesting chemical elements:

Iron (Fe) 9 atoms
Chlorine (Cl) 4 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site (pdb code 7owy). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site, PDB code: 7owy:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 7owy

Go back to Magnesium Binding Sites List in 7owy
Magnesium binding site 1 out of 2 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg211

b:14.9
occ:0.40
 O A:HOH349 1.9 27.7 1.0
O A:HOH582 1.9 17.4 0.4
O A:HOH635 2.0 17.3 0.4
O A:HOH637 2.0 48.9 1.0
O A:HOH569 2.1 33.8 1.0
O A:HOH410 2.4 18.6 1.0
O A:HOH642 4.0 56.8 1.0
OD1 A:ASN25 4.3 9.5 1.0
O A:HOH579 4.3 25.6 1.0
O A:HOH629 4.4 33.4 1.0
O A:HOH639 4.4 46.7 1.0
O A:ARG22 4.4 10.2 1.0
O A:HOH604 4.4 45.8 1.0
O A:HOH590 4.4 18.6 1.0
O A:HOH360 4.7 25.7 1.0
O A:HOH325 4.8 18.2 0.3
O A:HOH598 5.0 31.0 1.0
CB A:LEU26 5.0 9.2 1.0

Magnesium binding site 2 out of 2 in 7owy

Go back to Magnesium Binding Sites List in 7owy
Magnesium binding site 2 out of 2 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 3 Minutes Showing A Peroxide Anion As Bridging Species of Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg212

b:19.0
occ:0.40
 O A:HOH355 2.0 17.0 0.4
O A:HOH445 2.0 15.9 0.4
O A:HOH415 2.0 13.5 0.4
O A:HOH549 2.1 19.1 0.4
O A:HOH638 2.1 22.6 0.4
O A:HOH543 2.2 21.8 0.4
O A:HOH632 3.6 37.4 1.0
OG A:SER42 3.9 10.5 0.4
O A:HOH571 3.9 30.5 1.0
NH1 A:ARG53 4.0 22.2 0.5
OG A:SER52 4.2 11.8 1.0
OD1 A:ASN49 4.2 15.6 0.7
CB A:ASN49 4.3 12.5 1.0
CG A:ASN49 4.4 14.5 0.7
O A:ASN49 4.4 10.4 1.0
CB A:SER52 4.5 10.4 1.0
CG A:ARG53 4.7 14.4 0.5
O A:HOH413 4.7 30.0 1.0
CA A:ASN49 4.7 10.6 1.0
CB A:SER42 4.8 10.8 0.6

Reference:

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270
Page generated: Thu Oct 3 03:36:17 2024

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