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Atomistry » Magnesium » PDB 7pma-7pv7 » 7pqv | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 7pma-7pv7 » 7pqv » |
Magnesium in PDB 7pqv: MEK1 in Complex with Compound 7Enzymatic activity of MEK1 in Complex with Compound 7
All present enzymatic activity of MEK1 in Complex with Compound 7:
2.7.12.2; Protein crystallography data
The structure of MEK1 in Complex with Compound 7, PDB code: 7pqv
was solved by
H.Moebitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7pqv:
The structure of MEK1 in Complex with Compound 7 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the MEK1 in Complex with Compound 7
(pdb code 7pqv). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the MEK1 in Complex with Compound 7, PDB code: 7pqv: Magnesium binding site 1 out of 1 in 7pqvGo back to![]() ![]()
Magnesium binding site 1 out
of 1 in the MEK1 in Complex with Compound 7
![]() Mono view ![]() Stereo pair view
Reference:
R.Poddutoori,
K.Aardalen,
K.Aithal,
S.S.Barahagar,
C.Belliappa,
M.Bock,
S.Chelur,
A.Gerken,
S.Gopinath,
B.Gruenenfelder,
M.Kiffe,
M.Krishnaswami,
J.Langowski,
S.Madapa,
K.Narayanan,
C.Pandit,
S.K.Panigrahi,
M.Perrone,
R.K.Potakamuri,
M.Ramachandra,
A.Ramanathan,
R.Ramos,
E.Sager,
S.Samajdar,
H.S.Subramanya,
D.S.Thimmasandra,
E.Venetsanakos,
H.Mobitz.
Discovery of MAP855, An Efficacious and Selective MEK1/2 Inhibitor with An Atp-Competitive Mode of Action. J.Med.Chem. V. 65 4350 2022.
Page generated: Thu Apr 6 19:17:27 2023
ISSN: ISSN 0022-2623 PubMed: 35195996 DOI: 10.1021/ACS.JMEDCHEM.1C02192 |
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