Magnesium in PDB 7pxh: Emodepside-Bound Drosophila Slo Channel

The structure of Emodepside-Bound Drosophila Slo Channel also contains other interesting chemical elements:

Calcium	(Ca)	8 atoms
Potassium	(K)	6 atoms

The binding sites of Magnesium atom in the Emodepside-Bound Drosophila Slo Channel (pdb code 7pxh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Emodepside-Bound Drosophila Slo Channel, PDB code: 7pxh:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1203 b:45.9 occ:1.00 O A:ASN523 2.3 54.0 1.0 O A:THR547 2.5 56.6 1.0 O A:ALA526 2.6 56.2 1.0 O A:MET549 3.2 59.5 1.0 CG A:GLU550 3.3 59.6 1.0 C A:ASN523 3.6 54.0 1.0 CG A:ARG528 3.6 61.0 1.0 C A:THR547 3.7 56.6 1.0 C A:ALA526 3.7 56.2 1.0 OE2 A:GLU550 3.7 59.6 1.0 C A:MET549 4.0 59.5 1.0 CB A:ARG528 4.0 61.0 1.0 CD A:GLU550 4.0 59.6 1.0 N A:ALA526 4.1 56.2 1.0 C A:GLY548 4.2 56.7 1.0 N A:ARG528 4.2 61.0 1.0 N A:MET549 4.2 59.5 1.0 CA A:ALA526 4.4 56.2 1.0 CA A:GLY548 4.4 56.7 1.0 CA A:LEU524 4.4 53.4 1.0 N A:LEU524 4.4 53.4 1.0 CA A:ASN523 4.5 54.0 1.0 C A:LEU524 4.5 53.4 1.0 N A:GLY548 4.5 56.7 1.0 CB A:GLU550 4.5 59.6 1.0 O A:GLY548 4.6 56.7 1.0 CB A:ALA526 4.6 56.2 1.0 CA A:THR547 4.6 56.6 1.0 CA A:GLU550 4.7 59.6 1.0 N A:GLU550 4.7 59.6 1.0 CA A:ARG528 4.7 61.0 1.0 N A:PHE525 4.7 54.4 1.0 CA A:MET549 4.8 59.5 1.0 CB A:ASN523 4.8 54.0 1.0 N A:MET527 4.8 60.1 1.0 O A:LEU524 4.9 53.4 1.0 O A:ARG528 5.0 61.0 1.0 C A:MET527 5.0 60.1 1.0

Magnesium binding site 2 out of 4 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1203 b:46.3 occ:1.00 O B:ASN523 2.3 54.2 1.0 O B:THR547 2.5 56.4 1.0 O B:ALA526 2.6 56.4 1.0 O B:MET549 3.2 59.7 1.0 CG B:GLU550 3.3 60.0 1.0 C B:ASN523 3.6 54.2 1.0 CG B:ARG528 3.6 60.6 1.0 C B:THR547 3.7 56.4 1.0 C B:ALA526 3.7 56.4 1.0 OE2 B:GLU550 3.7 60.0 1.0 C B:MET549 4.0 59.7 1.0 CB B:ARG528 4.0 60.6 1.0 CD B:GLU550 4.0 60.0 1.0 N B:ALA526 4.1 56.4 1.0 C B:GLY548 4.2 57.1 1.0 N B:ARG528 4.2 60.6 1.0 N B:MET549 4.2 59.7 1.0 CA B:ALA526 4.4 56.4 1.0 CA B:GLY548 4.4 57.1 1.0 CA B:LEU524 4.4 53.7 1.0 N B:LEU524 4.4 53.7 1.0 CA B:ASN523 4.5 54.2 1.0 C B:LEU524 4.5 53.7 1.0 N B:GLY548 4.5 57.1 1.0 CB B:GLU550 4.5 60.0 1.0 O B:GLY548 4.6 57.1 1.0 CB B:ALA526 4.6 56.4 1.0 CA B:THR547 4.6 56.4 1.0 CA B:GLU550 4.7 60.0 1.0 N B:GLU550 4.7 60.0 1.0 CA B:ARG528 4.7 60.6 1.0 N B:PHE525 4.7 54.8 1.0 CA B:MET549 4.8 59.7 1.0 CB B:ASN523 4.8 54.2 1.0 N B:MET527 4.8 60.1 1.0 O B:LEU524 4.9 53.7 1.0 O B:ARG528 5.0 60.6 1.0 C B:MET527 5.0 60.1 1.0

Magnesium binding site 3 out of 4 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1203 b:69.8 occ:1.00 O C:ASN523 2.1 56.0 1.0 O C:MET549 2.1 59.1 1.0 C C:ASN523 2.8 56.0 1.0 O C:THR547 3.0 57.0 1.0 C C:MET549 3.2 59.1 1.0 O C:GLY546 3.2 58.9 1.0 C C:THR547 3.4 57.0 1.0 N C:LEU524 3.4 55.4 1.0 N C:MET549 3.5 59.1 1.0 CB C:ASN523 3.5 56.0 1.0 CA C:LEU524 3.6 55.4 1.0 CA C:THR547 3.6 57.0 1.0 CA C:ASN523 3.7 56.0 1.0 CA C:MET549 3.7 59.1 1.0 CB C:MET549 4.1 59.1 1.0 CD2 C:LEU524 4.1 55.4 1.0 C C:GLY546 4.2 58.9 1.0 N C:GLY548 4.2 55.7 1.0 N C:GLU550 4.3 58.8 1.0 C C:GLY548 4.4 55.7 1.0 CG C:LEU524 4.4 55.4 1.0 N C:THR547 4.4 57.0 1.0 C C:LEU524 4.5 55.4 1.0 CB C:LEU524 4.6 55.4 1.0 CG C:ASN523 4.7 56.0 1.0 CA C:GLU550 4.7 58.8 1.0 CA C:GLY548 4.8 55.7 1.0 CB C:THR547 4.8 57.0 1.0 O C:ALA526 4.8 59.2 1.0 N C:ASN523 5.0 56.0 1.0

Magnesium binding site 4 out of 4 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Mg1203 b:68.8 occ:1.00 O D:ASN523 2.1 55.7 1.0 O D:MET549 2.1 60.1 1.0 C D:ASN523 2.8 55.7 1.0 O D:THR547 3.0 57.4 1.0 C D:MET549 3.2 60.1 1.0 O D:GLY546 3.2 59.7 1.0 C D:THR547 3.4 57.4 1.0 N D:LEU524 3.4 55.3 1.0 N D:MET549 3.5 60.1 1.0 CB D:ASN523 3.5 55.7 1.0 CA D:LEU524 3.6 55.3 1.0 CA D:THR547 3.6 57.4 1.0 CA D:ASN523 3.7 55.7 1.0 CA D:MET549 3.7 60.1 1.0 CB D:MET549 4.1 60.1 1.0 CD2 D:LEU524 4.1 55.3 1.0 C D:GLY546 4.2 59.7 1.0 N D:GLY548 4.2 56.5 1.0 N D:GLU550 4.3 59.6 1.0 C D:GLY548 4.4 56.5 1.0 CG D:LEU524 4.4 55.3 1.0 N D:THR547 4.4 57.4 1.0 C D:LEU524 4.5 55.3 1.0 CB D:LEU524 4.6 55.3 1.0 CG D:ASN523 4.7 55.7 1.0 CA D:GLU550 4.7 59.6 1.0 CA D:GLY548 4.8 56.5 1.0 CB D:THR547 4.8 57.4 1.0 O D:ALA526 4.8 58.7 1.0 N D:ASN523 5.0 55.7 1.0

T.Raisch, A.Brockmann, U.Ebbinghaus-Kintscher, J.Freigang, O.Gutbrod, J.Kubicek, B.Maertens, O.Hofnagel, S.Raunser. Small Molecule Modulation of the Drosophila Slo Channel Elucidated By Cryo-Em To Be Published.
DOI: 10.1038/S41467-021-27435-W