Magnesium in PDB 7qtl: Influenza A/H7N9 Polymerase Elongation Complex

All present enzymatic activity of Influenza A/H7N9 Polymerase Elongation Complex:
2.7.7.48;

The binding sites of Magnesium atom in the Influenza A/H7N9 Polymerase Elongation Complex (pdb code 7qtl). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Influenza A/H7N9 Polymerase Elongation Complex, PDB code: 7qtl:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Influenza A/H7N9 Polymerase Elongation Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Influenza A/H7N9 Polymerase Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg902 b:22.2 occ:1.00 O B:HOH1015 2.0 19.9 1.0 O B:HOH1034 2.4 22.1 1.0 O B:HOH1021 2.6 18.3 1.0 O B:GLY304 2.7 16.4 1.0 OD1 B:ASP305 2.9 20.5 1.0 CG B:ASP305 3.2 20.5 1.0 C B:GLY304 3.3 16.4 1.0 OD2 B:ASP305 3.5 20.5 1.0 N B:ASP305 3.7 20.5 1.0 CB B:ASP446 3.8 20.6 1.0 CA B:ASP305 3.9 20.5 1.0 OE1 B:GLU491 3.9 21.5 1.0 CA B:ASP446 4.1 20.6 1.0 CB B:ASP305 4.1 20.5 1.0 N B:PHE447 4.2 17.4 1.0 N B:GLY304 4.2 16.4 1.0 OD1 B:ASP446 4.3 20.6 1.0 CA B:GLY304 4.3 16.4 1.0 O B:PHE447 4.4 17.4 1.0 CG B:ASP446 4.5 20.6 1.0 O B:GLU491 4.6 21.5 1.0 O M:HOH206 4.7 22.9 1.0 C B:ASP446 4.7 20.6 1.0 CG2 B:THR303 4.7 16.6 1.0 CD B:GLU491 4.8 21.5 1.0 OE2 B:GLU491 4.8 21.5 1.0 O B:HOH1002 4.9 20.1 1.0 C B:THR303 4.9 16.6 1.0

Magnesium binding site 2 out of 2 in the Influenza A/H7N9 Polymerase Elongation Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Influenza A/H7N9 Polymerase Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg903 b:37.4 occ:1.00 O B:HOH1025 2.0 30.2 1.0 O2B B:2TM901 2.2 19.5 1.0 O2A B:2TM901 2.5 19.5 1.0 O M:HOH206 2.9 22.9 1.0 O B:HOH1037 2.9 22.6 1.0 NZ B:LYS481 3.5 20.3 1.0 PB B:2TM901 3.5 19.5 1.0 OD2 B:ASP305 3.6 20.5 1.0 CG B:ASP305 3.7 20.5 1.0 PA B:2TM901 3.7 19.5 1.0 OD1 B:ASP305 3.9 20.5 1.0 O B:HOH1002 3.9 20.1 1.0 C1 B:2TM901 3.9 19.5 1.0 CD B:LYS481 4.1 20.3 1.0 NZ B:LYS235 4.2 20.0 1.0 CE B:LYS481 4.3 20.3 1.0 O1B B:2TM901 4.4 19.5 1.0 CB B:ASP305 4.4 20.5 1.0 O1A B:2TM901 4.4 19.5 1.0 O2G B:2TM901 4.4 19.5 1.0 O3' M:G18 4.5 24.7 1.0 O3B B:2TM901 4.6 19.5 1.0 O B:HOH1007 4.7 21.5 1.0 O5' B:2TM901 5.0 19.5 1.0

T.Kouba, S.Cusack. Direct Observation of Backtracking By Influenza A and B Polymerases Upon Consecutive Incorporation of Nucleoside Analogue T1106 Cell Rep 2022.
ISSN: ESSN 2211-1247
DOI: 10.1016/J.CELREP.2022.111901