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Magnesium in PDB 7r0m: KRASG12C in Complex with Gdp and JDQ443Protein crystallography data
The structure of KRASG12C in Complex with Gdp and JDQ443, PDB code: 7r0m
was solved by
N.Ostermann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7r0m:
The structure of KRASG12C in Complex with Gdp and JDQ443 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the KRASG12C in Complex with Gdp and JDQ443
(pdb code 7r0m). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the KRASG12C in Complex with Gdp and JDQ443, PDB code: 7r0m: Jump to Magnesium binding site number: 1; 2; 3; 4; Magnesium binding site 1 out of 4 in 7r0mGo back to Magnesium Binding Sites List in 7r0m
Magnesium binding site 1 out
of 4 in the KRASG12C in Complex with Gdp and JDQ443
Mono view Stereo pair view
Magnesium binding site 2 out of 4 in 7r0mGo back to Magnesium Binding Sites List in 7r0m
Magnesium binding site 2 out
of 4 in the KRASG12C in Complex with Gdp and JDQ443
Mono view Stereo pair view
Magnesium binding site 3 out of 4 in 7r0mGo back to Magnesium Binding Sites List in 7r0m
Magnesium binding site 3 out
of 4 in the KRASG12C in Complex with Gdp and JDQ443
Mono view Stereo pair view
Magnesium binding site 4 out of 4 in 7r0mGo back to Magnesium Binding Sites List in 7r0m
Magnesium binding site 4 out
of 4 in the KRASG12C in Complex with Gdp and JDQ443
Mono view Stereo pair view
Reference:
A.Weiss,
E.Lorthiois,
L.Barys,
K.S.Beyer,
C.Bomio-Confaglia,
H.Burks,
X.Chen,
X.Cui,
R.De Kanter,
L.Dharmarajan,
C.Fedele,
M.Gerspacher,
D.A.Guthy,
V.Head,
A.Jaeger,
E.J.Nunez,
J.D.Kearns,
C.Leblanc,
S.M.Maira,
J.Murphy,
H.Oakman,
N.Ostermann,
J.Ottl,
P.Rigollier,
D.Roman,
C.Schnell,
R.Sedrani,
T.Shimizu,
R.Stringer,
A.Vaupel,
H.Voshol,
P.Wessels,
T.Widmer,
R.Wilcken,
K.Xu,
F.Zecri,
A.F.Farago,
S.Cotesta,
S.M.Brachmann.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, A Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov V. 12 1500 2022.
Page generated: Thu Apr 6 21:03:32 2023
ISSN: ESSN 2159-8290 PubMed: 35404998 DOI: 10.1158/2159-8290.CD-22-0158 |
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