Magnesium in PDB 7rse: uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc

The binding sites of Magnesium atom in the uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc (pdb code 7rse). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc, PDB code: 7rse:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg202 b:10.0 occ:1.00 O3G A:GSP201 1.4 10.0 1.0 OD2 A:ASP57 1.6 10.0 1.0 OG A:SER17 1.7 10.0 1.0 OG1 A:THR35 1.8 10.0 1.0 HG A:SER17 2.1 10.0 1.0 O2B A:GSP201 2.6 10.0 1.0 HG1 A:THR35 2.6 10.0 1.0 CB A:THR35 2.7 10.0 1.0 CG A:ASP57 2.8 10.0 1.0 PG A:GSP201 2.9 10.0 1.0 CB A:SER17 3.0 10.0 1.0 OD1 A:ASP57 3.5 10.0 1.0 H A:SER17 3.5 10.0 1.0 CG2 A:THR35 3.5 10.0 1.0 H A:THR35 3.5 10.0 1.0 PB A:GSP201 3.7 10.0 1.0 N A:SER17 3.7 10.0 1.0 CA A:SER17 3.8 10.0 1.0 O3B A:GSP201 3.8 10.0 1.0 O2G A:GSP201 3.8 10.0 1.0 CB A:ASP57 3.9 10.0 1.0 O A:ASP33 4.0 10.0 1.0 S1G A:GSP201 4.0 10.0 1.0 CA A:THR35 4.0 10.0 1.0 N A:THR35 4.1 10.0 1.0 OD2 A:ASP33 4.1 10.0 1.0 O A:THR58 4.3 10.0 1.0 O3A A:GSP201 4.4 10.0 1.0 O1A A:GSP201 4.4 10.0 1.0 CB A:LYS16 4.6 10.0 1.0 C A:LYS16 4.6 10.0 1.0 PA A:GSP201 4.8 10.0 1.0 C A:THR35 4.9 10.0 1.0 O A:THR35 5.0 10.0 1.0 O1B A:GSP201 5.0 10.0 1.0

Magnesium binding site 2 out of 2 in the uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of uc(Nmr)-Driven Structure of the KRAS4B-G12D "Alpha-Beta" Dimer on A Lipid Bilayer Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg202 b:10.0 occ:1.00 O3G B:GSP201 1.4 10.0 1.0 OG B:SER17 1.7 10.0 1.0 HG B:SER17 2.2 10.0 1.0 O2B B:GSP201 2.4 10.0 1.0 PG B:GSP201 2.9 10.0 1.0 CB B:SER17 2.9 10.0 1.0 O2A B:GSP201 3.1 10.0 1.0 OD2 B:ASP57 3.2 10.0 1.0 PB B:GSP201 3.6 10.0 1.0 O3B B:GSP201 3.7 10.0 1.0 O2G B:GSP201 3.7 10.0 1.0 H B:SER17 3.8 10.0 1.0 S1G B:GSP201 4.0 10.0 1.0 CA B:SER17 4.1 10.0 1.0 PA B:GSP201 4.1 10.0 1.0 N B:SER17 4.2 10.0 1.0 O3A B:GSP201 4.3 10.0 1.0 CG B:ASP57 4.4 10.0 1.0 O1A B:GSP201 4.5 10.0 1.0 H B:THR35 4.8 10.0 1.0 O1B B:GSP201 4.8 10.0 1.0 OD1 B:ASP57 4.9 10.0 1.0

K.Y.Lee, M.Enomoto, T.Gebregiworgis, G.M.C.Gasmi-Seabrook, M.Ikura, C.B.Marshall. Oncogenic Kras G12D Mutation Promotes Dimerization Through A Second, Phosphatidylserine-Dependent Interface: A Model For Kras Oligomerization Chem Sci 2021.
ISSN: ESSN 2041-6539
DOI: 10.1039/D1SC03484G