Magnesium in PDB 7s9g: Room-Temperature Human HSP90A-Ntd Bound to BIIB021

All present enzymatic activity of Room-Temperature Human HSP90A-Ntd Bound to BIIB021:
3.6.4.10;

The structure of Room-Temperature Human HSP90A-Ntd Bound to BIIB021, PDB code: 7s9g was solved by T.R.Stachowski, M.Vanarotti, M.Fischer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.91 / 1.79
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	68.904, 90.772, 99.748, 90, 90, 90
R / Rfree (%)	17.6 / 19.6

The structure of Room-Temperature Human HSP90A-Ntd Bound to BIIB021 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Magnesium atom in the Room-Temperature Human HSP90A-Ntd Bound to BIIB021 (pdb code 7s9g). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Room-Temperature Human HSP90A-Ntd Bound to BIIB021, PDB code: 7s9g:

Magnesium binding site 1 out of 1 in the Room-Temperature Human HSP90A-Ntd Bound to BIIB021


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Room-Temperature Human HSP90A-Ntd Bound to BIIB021 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg302 b:69.7 occ:1.00 HD21 A:ASN79 3.2 48.3 1.0 OD1 A:ASN79 3.6 40.8 1.0 HZ A:PHE221 3.8 44.3 0.6 ND2 A:ASN79 3.8 40.2 1.0 HE1 A:PHE221 4.0 48.7 0.6 HG1 A:THR219 4.1 46.5 1.0 CG A:ASN79 4.1 41.7 1.0 NE2 A:HIS77 4.1 51.4 1.0 HE2 A:HIS77 4.1 61.6 1.0 HE1 A:PHE221 4.3 44.4 0.4 CD2 A:HIS77 4.4 54.6 1.0 CE1 A:HIS77 4.4 44.3 1.0 HG21 A:THR219 4.5 55.2 1.0 CZ A:PHE221 4.5 36.9 0.6 HB A:THR219 4.5 46.6 1.0 HD22 A:ASN79 4.5 48.3 1.0 O A:HOH426 4.6 43.6 1.0 HD2 A:HIS77 4.6 65.6 1.0 CE1 A:PHE221 4.6 40.6 0.6 HZ A:PHE221 4.6 43.4 0.4 HE1 A:HIS77 4.6 53.1 1.0 OG1 A:THR219 4.8 38.7 1.0 CG A:HIS77 4.8 42.9 1.0 ND1 A:HIS77 4.9 58.5 1.0

T.R.Stachowski, M.Vanarotti, J.Seetharaman, K.Lopez, M.Fischer. Water Networks Repopulate Protein-Ligand Interfaces with Temperature. Angew.Chem.Int.Ed.Engl. V. 61 12919 2022.
ISSN: ESSN 1521-3773
PubMed: 35648650
DOI: 10.1002/ANIE.202112919