Magnesium in PDB 7wl6: Crystal Structure of I73L Mutated Human Transthyretin

The structure of Crystal Structure of I73L Mutated Human Transthyretin, PDB code: 7wl6 was solved by M.Nakagawa, T.Obita, M.Mizuguchi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.67 / 1.42
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	42.84, 85.84, 64.16, 90, 90, 90
R / Rfree (%)	18.4 / 21

The binding sites of Magnesium atom in the Crystal Structure of I73L Mutated Human Transthyretin (pdb code 7wl6). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of I73L Mutated Human Transthyretin, PDB code: 7wl6:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of I73L Mutated Human Transthyretin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of I73L Mutated Human Transthyretin within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg201 b:41.2 occ:1.00 O A:HOH303 2.1 25.9 1.0 O A:HOH312 2.1 27.4 1.0 O A:HOH356 2.1 30.6 1.0 OE2 A:GLU66 3.6 28.9 1.0 OE1 A:GLU66 3.8 26.2 1.0 O A:ASP99 3.9 31.4 1.0 CD A:GLU66 4.1 29.5 1.0 O A:HOH372 4.8 44.7 1.0 C A:ASP99 5.0 30.1 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of I73L Mutated Human Transthyretin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of I73L Mutated Human Transthyretin within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg201 b:29.0 occ:1.00 O B:HOH319 2.0 33.0 1.0 O B:HOH305 2.0 25.8 1.0 O B:HOH311 2.1 40.6 1.0 OE2 B:GLU66 3.7 23.3 1.0 OD1 B:ASN98 4.0 44.6 1.0 OE1 B:GLU66 4.2 20.6 1.0 CD B:GLU66 4.3 19.5 1.0 O B:HOH356 4.6 29.3 1.0 O B:ASP99 4.7 57.9 1.0 O B:HOH371 4.8 50.9 1.0

M.Nakagawa, T.Obita, M.Mizuguchi. The Hydrophobic Residue LEU73 Is Crucial For the High Stability and Low Aggregation Properties of Murine Transthyretin. Biochem.J. V. 479 1999 2022.
ISSN: ESSN 1470-8728
PubMed: 36098398
DOI: 10.1042/BCJ20220203