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Atomistry » Magnesium » PDB 8aq5-8avq » 8aq7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 8aq5-8avq » 8aq7 » |
Magnesium in PDB 8aq7: Kras G12C in Complex with Gdp and Compound 9Protein crystallography data
The structure of Kras G12C in Complex with Gdp and Compound 9, PDB code: 8aq7
was solved by
N.Ostermann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Kras G12C in Complex with Gdp and Compound 9
(pdb code 8aq7). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Kras G12C in Complex with Gdp and Compound 9, PDB code: 8aq7: Jump to Magnesium binding site number: 1; 2; 3; Magnesium binding site 1 out of 3 in 8aq7Go back to Magnesium Binding Sites List in 8aq7
Magnesium binding site 1 out
of 3 in the Kras G12C in Complex with Gdp and Compound 9
Mono view Stereo pair view
Magnesium binding site 2 out of 3 in 8aq7Go back to Magnesium Binding Sites List in 8aq7
Magnesium binding site 2 out
of 3 in the Kras G12C in Complex with Gdp and Compound 9
Mono view Stereo pair view
Magnesium binding site 3 out of 3 in 8aq7Go back to Magnesium Binding Sites List in 8aq7
Magnesium binding site 3 out
of 3 in the Kras G12C in Complex with Gdp and Compound 9
Mono view Stereo pair view
Reference:
E.Lorthiois,
M.Gerspacher,
K.S.Beyer,
A.Vaupel,
C.Leblanc,
R.Stringer,
A.Weiss,
R.Wilcken,
D.A.Guthy,
A.Lingel,
C.Bomio-Confaglia,
R.Machauer,
P.Rigollier,
J.Ottl,
D.Arz,
P.Bernet,
G.Desjonqueres,
S.Dussauge,
M.Kazic-Legueux,
M.A.Lozac'h,
C.Mura,
M.Sorge,
M.Todorov,
N.Warin,
F.Zink,
H.Voshol,
F.J.Zecri,
R.C.Sedrani,
N.Ostermann,
S.M.Brachmann,
S.Cotesta.
JDQ443, A Structurally Novel, Pyrazole-Based, Covalent Inhibitor of Kras G12C For the Treatment of Solid Tumors. J.Med.Chem. V. 65 16173 2022.
Page generated: Thu Oct 3 18:41:18 2024
ISSN: ISSN 0022-2623 PubMed: 36399068 DOI: 10.1021/ACS.JMEDCHEM.2C01438 |
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