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Atomistry » Magnesium » PDB 8dtw-8e23 » 8e23 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 8dtw-8e23 » 8e23 » |
Magnesium in PDB 8e23: Human Dna Polymerase Theta in Complex with Allosteric InhibitorEnzymatic activity of Human Dna Polymerase Theta in Complex with Allosteric Inhibitor
All present enzymatic activity of Human Dna Polymerase Theta in Complex with Allosteric Inhibitor:
2.7.7.7; Protein crystallography data
The structure of Human Dna Polymerase Theta in Complex with Allosteric Inhibitor, PDB code: 8e23
was solved by
P.Mader,
V.P.T.Pau,
F.Sicheri,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8e23:
The structure of Human Dna Polymerase Theta in Complex with Allosteric Inhibitor also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Human Dna Polymerase Theta in Complex with Allosteric Inhibitor
(pdb code 8e23). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human Dna Polymerase Theta in Complex with Allosteric Inhibitor, PDB code: 8e23: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 8e23Go back to Magnesium Binding Sites List in 8e23
Magnesium binding site 1 out
of 2 in the Human Dna Polymerase Theta in Complex with Allosteric Inhibitor
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 8e23Go back to Magnesium Binding Sites List in 8e23
Magnesium binding site 2 out
of 2 in the Human Dna Polymerase Theta in Complex with Allosteric Inhibitor
Mono view Stereo pair view
Reference:
M.Bubenik,
P.Mader,
P.Mochirian,
F.Vallee,
J.Clark,
J.F.Truchon,
A.L.Perryman,
V.Pau,
I.Kurinov,
K.E.Zahn,
M.E.Leclaire,
R.Papp,
M.C.Mathieu,
M.Hamel,
N.M.Duffy,
C.Godbout,
M.Casas-Selves,
J.P.Falgueyret,
P.S.Baruah,
O.Nicolas,
R.Stocco,
H.Poirier,
G.Martino,
A.B.Fortin,
A.Roulston,
A.Chefson,
S.Dorich,
M.St-Onge,
P.Patel,
C.Pellerin,
S.Ciblat,
T.Pinter,
F.Barabe,
M.El Bakkouri,
P.Parikh,
C.Gervais,
A.Sfeir,
Y.Mamane,
S.J.Morris,
W.C.Black,
F.Sicheri,
M.Gallant.
Identification of Rp-6685 , An Orally Bioavailable Compound That Inhibits the Dna Polymerase Activity of Pol Theta. J.Med.Chem. V. 65 13198 2022.
Page generated: Fri Oct 4 01:00:06 2024
ISSN: ISSN 0022-2623 PubMed: 36126059 DOI: 10.1021/ACS.JMEDCHEM.2C00998 |
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