Magnesium in PDB 8k7c: Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)

All present enzymatic activity of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound):
7.6.2.5;

The structure of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) also contains other interesting chemical elements:

Vanadium

(V)

2 atoms

The binding sites of Magnesium atom in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) (pdb code 8k7c). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound), PDB code: 8k7c:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg903 b:119.8 occ:1.00 OG A:SER630 1.9 95.0 1.0 OE1 A:GLN671 1.9 97.3 1.0 O3B A:ADP901 2.1 102.4 1.0 O4 A:VO4902 2.2 121.1 1.0 CD A:GLN671 2.7 97.3 1.0 NE2 A:GLN671 2.9 97.3 1.0 CB A:SER630 3.2 95.0 1.0 PB A:ADP901 3.3 102.4 1.0 O1B A:ADP901 3.7 102.4 1.0 O2A A:ADP901 3.8 102.4 1.0 V A:VO4902 3.9 121.1 1.0 CA B:GLY729 4.1 96.7 1.0 CG A:GLN671 4.2 97.3 1.0 CA A:SER630 4.3 95.0 1.0 O3A A:ADP901 4.4 102.4 1.0 O2B A:ADP901 4.4 102.4 1.0 PA A:ADP901 4.4 102.4 1.0 OD2 A:ASP751 4.5 97.7 1.0 O2 A:VO4902 4.5 121.1 1.0 N B:GLY729 4.5 96.7 1.0 N A:SER630 4.6 95.0 1.0 CB A:GLN671 4.7 97.3 1.0 O1A A:ADP901 4.7 102.4 1.0 OD1 A:ASP751 4.9 97.7 1.0 O3 A:VO4902 4.9 121.1 1.0

Magnesium binding site 2 out of 2 in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg903 b:100.3 occ:1.00 OG B:SER630 1.8 89.5 1.0 O2 B:VO4902 2.1 106.5 1.0 OE1 B:GLN671 2.5 90.5 1.0 O3B B:ADP901 2.6 99.4 1.0 CB B:SER630 2.8 89.5 1.0 O2B B:ADP901 2.9 99.4 1.0 NE2 B:GLN671 2.9 90.5 1.0 CD B:GLN671 3.0 90.5 1.0 PB B:ADP901 3.2 99.4 1.0 O2A B:ADP901 3.5 99.4 1.0 CA A:GLY729 3.8 94.9 1.0 V B:VO4902 3.9 106.5 1.0 PA B:ADP901 4.1 99.4 1.0 CA B:SER630 4.1 89.5 1.0 O3A B:ADP901 4.1 99.4 1.0 N A:GLY729 4.2 94.9 1.0 O1A B:ADP901 4.2 99.4 1.0 N B:SER630 4.4 89.5 1.0 O1B B:ADP901 4.5 99.4 1.0 CG B:GLN671 4.5 90.5 1.0 O1 B:VO4902 4.6 106.5 1.0 C A:GLY729 4.8 94.9 1.0 O3 B:VO4902 4.9 106.5 1.0

S.S.Lee, J.G.Park, E.Jang, S.H.Choi, S.Kim, J.W.Kim, M.S.Jin. W546 Stacking Disruption Traps the Human Porphyrin Transporter ABCB6 in An Outward-Facing Transient State. Commun Biol V. 6 960 2023.
ISSN: ESSN 2399-3642
PubMed: 37735522
DOI: 10.1038/S42003-023-05339-3