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Atomistry » Magnesium » PDB 8pex-8pp4 » 8po4 » |
Magnesium in PDB 8po4: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R]Enzymatic activity of Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R]
All present enzymatic activity of Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R]:
2.7.10.1; Protein crystallography data
The structure of Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R], PDB code: 8po4
was solved by
D.Hargreaves,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R]
(pdb code 8po4). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R], PDB code: 8po4: Magnesium binding site 1 out of 1 in 8po4Go back to Magnesium Binding Sites List in 8po4
Magnesium binding site 1 out
of 1 in the Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. Compound 33 Bound to Egfr[V948R]
Mono view Stereo pair view
Reference:
C.Thomson,
P.Barton,
E.Braybrooke,
N.Colclough,
Z.Dong,
L.Evans,
N.Floc'h,
C.Guerot,
D.Hargreaves,
P.Khurana,
S.Li,
X.Li,
A.Lister,
W.Mccoull,
L.Mcwilliams,
J.P.Orme,
M.J.Packer,
A.M.Swaih,
R.A.Ward,
P.Winlow,
Y.Ye.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting Egfr EXON20 Insertion Mutations. J.Med.Chem. 2024.
Page generated: Fri Oct 4 16:07:02 2024
ISSN: ISSN 0022-2623 PubMed: 38770784 DOI: 10.1021/ACS.JMEDCHEM.4C00227 |
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