Magnesium in PDB 8s09: H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Enzymatic activity of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
All present enzymatic activity of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna:
3.6.4.12;
Other elements in 8s09:
The structure of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
(pdb code 8s09). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 8 binding sites of Magnesium where determined in the
H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna, PDB code: 8s09:
Jump to Magnesium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Magnesium binding site 1 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 1 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
2:Mg1002
b:27.8
occ:1.00
|
OG
|
2:SER530
|
2.1
|
26.5
|
1.0
|
O1G
|
2:ATP1001
|
2.3
|
32.4
|
1.0
|
O1B
|
2:ATP1001
|
2.3
|
32.4
|
1.0
|
CB
|
2:SER530
|
3.4
|
26.5
|
1.0
|
PB
|
2:ATP1001
|
3.5
|
32.4
|
1.0
|
PG
|
2:ATP1001
|
3.5
|
32.4
|
1.0
|
OD2
|
2:ASP587
|
3.6
|
28.4
|
1.0
|
O3B
|
2:ATP1001
|
3.7
|
32.4
|
1.0
|
O2A
|
2:ATP1001
|
3.8
|
32.4
|
1.0
|
OD1
|
2:ASP587
|
3.9
|
28.4
|
1.0
|
CG
|
2:ASP587
|
4.2
|
28.4
|
1.0
|
O3A
|
2:ATP1001
|
4.3
|
32.4
|
1.0
|
N
|
2:SER530
|
4.4
|
26.5
|
1.0
|
CA
|
2:SER530
|
4.5
|
26.5
|
1.0
|
O2G
|
2:ATP1001
|
4.5
|
32.4
|
1.0
|
O3G
|
2:ATP1001
|
4.6
|
32.4
|
1.0
|
PA
|
2:ATP1001
|
4.7
|
32.4
|
1.0
|
O2B
|
2:ATP1001
|
4.8
|
32.4
|
1.0
|
|
Magnesium binding site 2 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 2 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
3:Mg902
b:23.6
occ:1.00
|
OG
|
3:SER352
|
2.1
|
31.1
|
1.0
|
O1B
|
3:ADP901
|
2.3
|
41.1
|
1.0
|
O3B
|
3:ADP901
|
2.8
|
41.1
|
1.0
|
PB
|
3:ADP901
|
3.0
|
41.1
|
1.0
|
OE1
|
5:GLU463
|
3.1
|
39.3
|
1.0
|
CB
|
3:SER352
|
3.4
|
31.1
|
1.0
|
O2A
|
3:ADP901
|
3.7
|
41.1
|
1.0
|
OD2
|
3:ASP409
|
4.1
|
30.8
|
1.0
|
O2B
|
3:ADP901
|
4.1
|
41.1
|
1.0
|
N
|
3:SER352
|
4.1
|
31.1
|
1.0
|
OD1
|
3:ASP409
|
4.1
|
30.8
|
1.0
|
O3A
|
3:ADP901
|
4.2
|
41.1
|
1.0
|
CD
|
5:GLU463
|
4.3
|
39.3
|
1.0
|
CA
|
3:SER352
|
4.3
|
31.1
|
1.0
|
PA
|
3:ADP901
|
4.4
|
41.1
|
1.0
|
NH2
|
5:ARG513
|
4.5
|
39.0
|
1.0
|
CG
|
3:ASP409
|
4.6
|
30.8
|
1.0
|
OE2
|
5:GLU463
|
4.8
|
39.3
|
1.0
|
O1A
|
3:ADP901
|
4.8
|
41.1
|
1.0
|
CE
|
3:LYS351
|
4.8
|
32.3
|
1.0
|
|
Magnesium binding site 3 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 3 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
6:Mg901
b:36.5
occ:1.00
|
OG
|
6:SER403
|
2.1
|
37.0
|
1.0
|
O1B
|
4:ADP902
|
2.3
|
42.2
|
1.0
|
O3B
|
4:ADP902
|
2.3
|
42.2
|
1.0
|
PB
|
4:ADP902
|
2.8
|
42.2
|
1.0
|
CB
|
6:SER403
|
3.4
|
37.0
|
1.0
|
OD2
|
6:ASP460
|
3.7
|
35.8
|
1.0
|
O2A
|
4:ADP902
|
3.7
|
42.2
|
1.0
|
O2B
|
4:ADP902
|
3.9
|
42.2
|
1.0
|
O3A
|
4:ADP902
|
4.0
|
42.2
|
1.0
|
OD1
|
6:ASP460
|
4.2
|
35.8
|
1.0
|
OE2
|
6:GLU461
|
4.3
|
38.4
|
1.0
|
N
|
6:SER403
|
4.3
|
37.0
|
1.0
|
PA
|
4:ADP902
|
4.3
|
42.2
|
1.0
|
CA
|
6:SER403
|
4.4
|
37.0
|
1.0
|
CG
|
6:ASP460
|
4.4
|
35.8
|
1.0
|
NH2
|
4:ARG643
|
4.5
|
32.7
|
1.0
|
O1A
|
4:ADP902
|
4.8
|
42.2
|
1.0
|
CE
|
6:LYS402
|
4.8
|
38.3
|
1.0
|
|
Magnesium binding site 4 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 4 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 4 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
7:Mg802
b:46.2
occ:1.00
|
O3B
|
7:ADP801
|
2.0
|
51.6
|
1.0
|
OG
|
7:SER388
|
2.1
|
39.4
|
1.0
|
O1B
|
7:ADP801
|
2.1
|
51.6
|
1.0
|
PB
|
7:ADP801
|
2.4
|
51.6
|
1.0
|
OE2
|
7:GLU446
|
3.1
|
38.8
|
1.0
|
O2A
|
7:ADP801
|
3.4
|
51.6
|
1.0
|
CB
|
7:SER388
|
3.5
|
39.4
|
1.0
|
O3A
|
7:ADP801
|
3.6
|
51.6
|
1.0
|
O2B
|
7:ADP801
|
3.6
|
51.6
|
1.0
|
OD2
|
7:ASP445
|
3.7
|
35.2
|
1.0
|
PA
|
7:ADP801
|
3.9
|
51.6
|
1.0
|
NE2
|
3:HIS423
|
4.0
|
40.3
|
1.0
|
OD1
|
7:ASP445
|
4.0
|
35.2
|
1.0
|
N
|
7:SER388
|
4.3
|
39.4
|
1.0
|
CG
|
7:ASP445
|
4.3
|
35.2
|
1.0
|
O1A
|
7:ADP801
|
4.3
|
51.6
|
1.0
|
CD
|
7:GLU446
|
4.4
|
38.8
|
1.0
|
CA
|
7:SER388
|
4.4
|
39.4
|
1.0
|
CE1
|
3:HIS423
|
4.7
|
40.3
|
1.0
|
|
Magnesium binding site 5 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 5 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 5 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mg1002
b:27.8
occ:1.00
|
OG
|
A:SER530
|
2.1
|
26.5
|
1.0
|
O1G
|
A:ATP1001
|
2.3
|
32.4
|
1.0
|
O1B
|
A:ATP1001
|
2.3
|
32.4
|
1.0
|
CB
|
A:SER530
|
3.4
|
26.5
|
1.0
|
PB
|
A:ATP1001
|
3.5
|
32.4
|
1.0
|
PG
|
A:ATP1001
|
3.5
|
32.4
|
1.0
|
OD2
|
A:ASP587
|
3.6
|
28.4
|
1.0
|
O3B
|
A:ATP1001
|
3.7
|
32.4
|
1.0
|
O2A
|
A:ATP1001
|
3.8
|
32.4
|
1.0
|
OD1
|
A:ASP587
|
3.9
|
28.4
|
1.0
|
CG
|
A:ASP587
|
4.2
|
28.4
|
1.0
|
O3A
|
A:ATP1001
|
4.3
|
32.4
|
1.0
|
N
|
A:SER530
|
4.4
|
26.5
|
1.0
|
CA
|
A:SER530
|
4.5
|
26.5
|
1.0
|
O2G
|
A:ATP1001
|
4.5
|
32.4
|
1.0
|
O3G
|
A:ATP1001
|
4.6
|
32.4
|
1.0
|
PA
|
A:ATP1001
|
4.7
|
32.4
|
1.0
|
O2B
|
A:ATP1001
|
4.8
|
32.4
|
1.0
|
|
Magnesium binding site 6 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 6 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 6 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mg902
b:23.6
occ:1.00
|
OG
|
B:SER352
|
2.1
|
31.1
|
1.0
|
O1B
|
B:ADP901
|
2.3
|
41.1
|
1.0
|
O3B
|
B:ADP901
|
2.8
|
41.1
|
1.0
|
PB
|
B:ADP901
|
3.0
|
41.1
|
1.0
|
OE1
|
D:GLU463
|
3.1
|
39.3
|
1.0
|
CB
|
B:SER352
|
3.4
|
31.1
|
1.0
|
O2A
|
B:ADP901
|
3.7
|
41.1
|
1.0
|
OD2
|
B:ASP409
|
4.1
|
30.8
|
1.0
|
O2B
|
B:ADP901
|
4.1
|
41.1
|
1.0
|
N
|
B:SER352
|
4.1
|
31.1
|
1.0
|
OD1
|
B:ASP409
|
4.1
|
30.8
|
1.0
|
O3A
|
B:ADP901
|
4.2
|
41.1
|
1.0
|
CD
|
D:GLU463
|
4.3
|
39.3
|
1.0
|
CA
|
B:SER352
|
4.3
|
31.1
|
1.0
|
PA
|
B:ADP901
|
4.4
|
41.1
|
1.0
|
NH2
|
D:ARG513
|
4.5
|
39.0
|
1.0
|
CG
|
B:ASP409
|
4.6
|
30.8
|
1.0
|
OE2
|
D:GLU463
|
4.8
|
39.3
|
1.0
|
O1A
|
B:ADP901
|
4.8
|
41.1
|
1.0
|
CE
|
B:LYS351
|
4.8
|
32.3
|
1.0
|
|
Magnesium binding site 7 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 7 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 7 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Mg901
b:36.5
occ:1.00
|
OG
|
E:SER403
|
2.1
|
37.0
|
1.0
|
O1B
|
C:ADP902
|
2.3
|
42.2
|
1.0
|
O3B
|
C:ADP902
|
2.3
|
42.2
|
1.0
|
PB
|
C:ADP902
|
2.8
|
42.2
|
1.0
|
CB
|
E:SER403
|
3.4
|
37.0
|
1.0
|
O2A
|
C:ADP902
|
3.7
|
42.2
|
1.0
|
OD2
|
E:ASP460
|
3.7
|
35.8
|
1.0
|
O2B
|
C:ADP902
|
3.9
|
42.2
|
1.0
|
O3A
|
C:ADP902
|
4.0
|
42.2
|
1.0
|
OD1
|
E:ASP460
|
4.2
|
35.8
|
1.0
|
OE2
|
E:GLU461
|
4.3
|
38.4
|
1.0
|
N
|
E:SER403
|
4.3
|
37.0
|
1.0
|
PA
|
C:ADP902
|
4.3
|
42.2
|
1.0
|
CA
|
E:SER403
|
4.4
|
37.0
|
1.0
|
CG
|
E:ASP460
|
4.4
|
35.8
|
1.0
|
NH2
|
C:ARG643
|
4.5
|
32.7
|
1.0
|
O1A
|
C:ADP902
|
4.8
|
42.2
|
1.0
|
CE
|
E:LYS402
|
4.8
|
38.3
|
1.0
|
|
Magnesium binding site 8 out
of 8 in 8s09
Go back to
Magnesium Binding Sites List in 8s09
Magnesium binding site 8 out
of 8 in the H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna
Mono view
Stereo pair view
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 8 of H. Sapiens MCM2-7 Double Hexamer Bound to Double Stranded Dna within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Mg802
b:46.2
occ:1.00
|
O3B
|
F:ADP801
|
2.0
|
51.6
|
1.0
|
OG
|
F:SER388
|
2.1
|
39.4
|
1.0
|
O1B
|
F:ADP801
|
2.1
|
51.6
|
1.0
|
PB
|
F:ADP801
|
2.4
|
51.6
|
1.0
|
OE2
|
F:GLU446
|
3.1
|
38.8
|
1.0
|
O2A
|
F:ADP801
|
3.4
|
51.6
|
1.0
|
CB
|
F:SER388
|
3.5
|
39.4
|
1.0
|
O3A
|
F:ADP801
|
3.6
|
51.6
|
1.0
|
O2B
|
F:ADP801
|
3.6
|
51.6
|
1.0
|
OD2
|
F:ASP445
|
3.7
|
35.2
|
1.0
|
PA
|
F:ADP801
|
3.9
|
51.6
|
1.0
|
NE2
|
B:HIS423
|
4.0
|
40.3
|
1.0
|
OD1
|
F:ASP445
|
4.0
|
35.2
|
1.0
|
N
|
F:SER388
|
4.3
|
39.4
|
1.0
|
CG
|
F:ASP445
|
4.3
|
35.2
|
1.0
|
O1A
|
F:ADP801
|
4.3
|
51.6
|
1.0
|
CD
|
F:GLU446
|
4.4
|
38.8
|
1.0
|
CA
|
F:SER388
|
4.4
|
39.4
|
1.0
|
CE1
|
B:HIS423
|
4.7
|
40.3
|
1.0
|
|
Reference:
F.Weissmann,
J.F.Greiwe,
T.Puehringer,
E.L.Eastwood,
E.C.Couves,
T.C.R.Miller,
J.F.X.Diffley,
A.Costa.
Mcm Double Hexamer Loading Visualised with Human Proteins Nature 2024.
ISSN: ESSN 1476-4687
Page generated: Thu Oct 31 22:10:34 2024
|