Magnesium in PDB 8t4s: Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit

All present enzymatic activity of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit:
4.2.99.18;

The structure of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 50; Page 6, Binding sites: 51 - 60; Page 7, Binding sites: 61 - 70; Page 8, Binding sites: 71 - 80; Page 9, Binding sites: 81 - 90; Page 10, Binding sites: 91 - 97;

Binding sites:

The binding sites of Magnesium atom in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit (pdb code 8t4s). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 97 binding sites of Magnesium where determined in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit, PDB code: 8t4s:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Magnesium binding site 1 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1901 b:40.5 occ:1.00 O6 2:G431 3.9 35.2 1.0 O6 2:G432 4.0 35.8 1.0 N7 2:G431 4.5 27.3 1.0 N4 2:C430 4.5 24.4 1.0 O4 2:U97 4.7 38.1 1.0 OP1 2:U428 4.8 44.9 1.0 C6 2:G431 4.8 28.1 1.0 N4 2:C98 4.9 32.2 1.0 C5 2:C430 5.0 26.5 1.0

Magnesium binding site 2 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1902 b:98.8 occ:1.00 OP2 2:G1048 3.6 81.6 1.0 N7 2:G1068 3.6 84.2 1.0 OP2 2:C1047 3.8 82.8 1.0 OP2 2:C1067 4.0 94.3 1.0 O6 2:G1068 4.0 84.6 1.0 N7 2:G1048 4.1 78.0 1.0 P 2:C1047 4.4 78.7 1.0 O5' 2:C1047 4.4 86.3 1.0 OP1 2:C1047 4.4 82.2 1.0 C5 2:G1068 4.5 81.7 1.0 C6 2:G1068 4.7 81.6 1.0 C8 2:G1068 4.7 84.2 1.0 C8 2:G1048 4.8 77.1 1.0 OP2 2:G1068 4.9 85.8 1.0

Magnesium binding site 3 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1903 b:56.5 occ:1.00 O 2:HOH2002 3.9 15.8 1.0 O6 2:G1352 4.1 37.2 1.0 O6 2:G1351 4.2 36.7 1.0 N7 2:G1351 4.3 32.9 1.0 N7 2:G1352 4.5 27.8 1.0 N6 2:A1353 4.6 32.8 1.0 O4 2:U1359 4.6 33.9 1.0 C6 2:G1351 4.8 27.8 1.0 C5 2:G1351 4.8 23.8 1.0 C6 2:G1352 5.0 28.7 1.0

Magnesium binding site 4 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1904 b:89.0 occ:1.00 N6 2:A813 3.9 31.8 1.0 N7 2:A812 4.1 34.3 1.0 N7 2:A813 4.2 32.0 1.0 O4 2:U814 4.4 38.2 1.0 C8 2:A812 4.5 34.9 1.0 O3' 2:A811 4.6 47.1 1.0 O2' 2:G412 4.8 39.0 1.0 C6 2:A813 4.8 28.1 1.0 C5 2:A813 4.9 21.3 1.0 O2 2:C851 4.9 70.8 1.0 C4 2:U814 4.9 29.6 1.0 C3' 2:A811 5.0 44.4 1.0

Magnesium binding site 5 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1905 b:70.5 occ:1.00 OP2 2:A1199 3.3 32.6 1.0 N7 2:A1200 3.8 30.0 1.0 OP2 2:A1200 4.3 38.5 1.0 C8 2:A1199 4.4 25.3 1.0 N7 2:A1199 4.4 25.6 1.0 N6 2:A1200 4.6 29.4 1.0 P 2:A1199 4.6 21.5 1.0 C8 2:A1200 4.7 27.7 1.0 C5 2:A1200 4.9 23.0 1.0

Magnesium binding site 6 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range:

Magnesium binding site 7 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 7 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1907 b:87.3 occ:1.00 O 2:HOH2003 2.9 45.0 1.0 O 2:HOH2004 3.2 46.7 1.0 OP2 2:G1197 3.7 41.0 1.0 N7 2:G1197 4.0 33.5 1.0 OP2 2:A1196 4.3 49.5 1.0 O2' 2:U8 4.4 42.6 1.0 C8 2:G1197 4.5 34.2 1.0 O2 2:U8 5.0 39.9 1.0

Magnesium binding site 8 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 8 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1908 b:65.5 occ:1.00 O 2:HOH2001 3.8 44.1 1.0 O4 2:U87 3.8 37.6 1.0 O4 2:U57 4.0 34.7 1.0 O6 2:G88 4.0 36.0 1.0 C5 2:U87 4.4 28.3 1.0 C4 2:U87 4.4 25.5 1.0 N4 2:C89 4.6 27.5 1.0 N7 2:G88 4.8 18.3 1.0 OP2 2:C86 4.9 44.3 1.0 O6 2:G56 4.9 36.7 1.0

Magnesium binding site 9 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 9 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1909 b:67.5 occ:1.00 OP2 2:U9 3.6 40.0 1.0 OP1 2:U8 3.9 44.5 1.0 C5 2:U9 4.0 33.0 1.0 OP2 2:A11 4.2 38.0 1.0 OP1 2:A11 4.3 32.8 1.0 C6 2:U9 4.4 37.0 1.0 OP2 2:G10 4.7 43.1 1.0 O5' 2:U9 4.7 38.0 1.0 P 2:A11 4.7 29.3 1.0 C4 2:U9 4.8 31.9 1.0 P 2:U9 4.8 29.8 1.0 O5' 2:U8 4.8 39.6 1.0 P 2:U8 5.0 48.0 1.0

Magnesium binding site 10 out of 97 in the Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 10 of Mers-Cov NSP1 Protein Bound to the Human 40S Ribosomal Subunit within 5.0Å range: probe atom residue distance (Å) B Occ 2:Mg1910 b:118.6 occ:1.00 O6 2:G976 4.0 101.5 1.0 O6 2:G975 4.0 105.0 1.0 N7 2:G975 4.2 103.9 1.0 N7 2:G976 4.6 98.0 1.0 C6 2:G975 4.6 103.3 1.0 C5 2:G975 4.7 102.4 1.0 C6 2:G976 4.9 98.8 1.0

S.C.Devarkar, M.Vetick, S.Balaji, I.B.Lomakin, L.Yang, D.Jin, W.V.Gilbert, S.Chen, Y.Xiong. Structural Basis For Translation Inhibition By Mers-Cov NSP1 Reveals A Conserved Mechanism For Betacoronaviruses Cell Rep 2023.
ISSN: ESSN 2211-1247
DOI: 10.1016/J.CELREP.2023.113156