Magnesium in PDB 8tul: Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition

Magnesium Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 14;

Binding sites:

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition (pdb code 8tul). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 14 binding sites of Magnesium where determined in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition, PDB code: 8tul:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Magnesium binding site 1 out of 14 in 8tul

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Magnesium binding site 1 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


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Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg501

b:33.6
occ:1.00
 O A:HOH656 3.0 40.2 1.0
O A:GLU243 3.0 21.9 1.0
O A:HOH641 3.1 24.2 1.0
OE2 B:GLU312 3.3 23.4 1.0
OD1 A:ASP247 3.3 29.9 1.0
CA A:GLU243 3.6 5.3 1.0
CB A:GLU243 3.7 9.4 1.0
C A:GLU243 3.7 12.6 1.0
O B:HOH617 3.8 22.0 1.0
CB A:THR246 4.0 10.3 1.0
CG A:ASP247 4.0 31.6 1.0
CD B:GLU312 4.2 13.3 1.0
OD2 A:ASP247 4.2 37.5 1.0
OE1 B:GLU312 4.2 17.6 1.0
CG A:GLU243 4.3 16.4 1.0
O A:HOH648 4.3 43.6 1.0
CG2 A:THR246 4.4 14.5 1.0
N A:ASP247 4.5 8.4 1.0
OG1 A:THR246 4.6 19.6 1.0
OE1 A:GLU138 4.9 51.3 1.0
C A:THR246 5.0 8.3 1.0
CA A:THR246 5.0 6.5 1.0
N A:LEU244 5.0 17.2 1.0

Magnesium binding site 2 out of 14 in 8tul

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Magnesium binding site 2 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg502

b:65.0
occ:1.00
 O E:HOH645 2.1 65.0 1.0
O E:HOH650 2.9 64.4 1.0
O E:HOH651 2.9 59.2 1.0
O A:HOH640 3.6 44.0 1.0
O A:HOH628 4.0 43.6 1.0
O A:HOH637 4.0 47.4 1.0
O A:HOH623 4.1 56.0 1.0
CD A:GLU293 4.3 62.3 1.0
CD2 E:LEU264 4.3 67.8 1.0
OE2 A:GLU297 4.4 44.9 1.0
OE1 A:GLU293 4.4 60.9 1.0
OE2 A:GLU293 4.5 60.9 1.0
OE1 E:GLU261 4.5 70.0 1.0
CG A:GLU293 4.7 55.8 1.0
OE1 A:GLU297 4.8 47.1 1.0
CG E:LEU264 4.9 67.3 1.0

Magnesium binding site 3 out of 14 in 8tul

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Magnesium binding site 3 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg503

b:30.0
occ:1.00
 O B:GLY360 3.8 47.5 1.0
O C:GLY360 3.8 47.5 1.0
O D:GLY360 3.8 47.5 1.0
O A:GLY360 3.8 47.5 1.0
O E:GLY360 3.9 47.5 1.0
OD1 C:ASN362 4.2 55.5 1.0
OD1 B:ASN362 4.2 55.5 1.0
OD1 D:ASN362 4.2 55.5 1.0
OD1 E:ASN362 4.2 55.5 1.0
OD1 A:ASN362 4.2 55.5 1.0
C B:GLY360 4.9 48.5 1.0
C C:GLY360 4.9 48.5 1.0
C A:GLY360 4.9 48.5 1.0
C D:GLY360 4.9 48.5 1.0
C E:GLY360 5.0 48.5 1.0

Magnesium binding site 4 out of 14 in 8tul

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Magnesium binding site 4 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg504

b:30.0
occ:1.00
 OD1 A:ASN339 4.3 23.2 1.0
OD1 B:ASN339 4.3 23.2 1.0
OD1 E:ASN339 4.3 23.2 1.0
OD1 C:ASN339 4.3 23.2 1.0
OD1 D:ASN339 4.3 23.2 1.0
CG A:ASN339 4.9 16.6 1.0
CG E:ASN339 4.9 16.6 1.0
CG B:ASN339 4.9 16.6 1.0
CG D:ASN339 4.9 16.6 1.0
CG C:ASN339 5.0 16.6 1.0

Magnesium binding site 5 out of 14 in 8tul

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Magnesium binding site 5 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:

Magnesium binding site 6 out of 14 in 8tul

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Magnesium binding site 6 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg500

b:65.0
occ:1.00
 O A:HOH646 2.1 65.0 1.0
O A:HOH651 2.9 64.4 1.0
O A:HOH652 2.9 59.2 1.0
O B:HOH639 3.6 44.0 1.0
O B:HOH627 4.0 43.6 1.0
O B:HOH637 4.0 47.4 1.0
O B:HOH624 4.1 56.0 1.0
CD B:GLU293 4.3 62.3 1.0
CD2 A:LEU264 4.3 67.8 1.0
OE2 B:GLU297 4.4 44.9 1.0
OE1 B:GLU293 4.4 60.9 1.0
OE2 B:GLU293 4.4 60.9 1.0
OE1 A:GLU261 4.5 70.0 1.0
CG B:GLU293 4.7 55.8 1.0
OE1 B:GLU297 4.7 47.1 1.0
CG A:LEU264 4.9 67.3 1.0
CD B:GLU297 5.0 46.7 1.0

Magnesium binding site 7 out of 14 in 8tul

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Magnesium binding site 7 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 7 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg501

b:33.6
occ:1.00
 O B:HOH655 3.0 40.2 1.0
O B:GLU243 3.0 21.9 1.0
O B:HOH641 3.1 24.2 1.0
OE2 C:GLU312 3.3 23.4 1.0
OD1 B:ASP247 3.3 29.9 1.0
CA B:GLU243 3.6 5.3 1.0
CB B:GLU243 3.7 9.4 1.0
C B:GLU243 3.7 12.6 1.0
O C:HOH617 3.8 22.0 1.0
CB B:THR246 4.0 10.3 1.0
CG B:ASP247 4.0 31.6 1.0
CD C:GLU312 4.2 13.3 1.0
OD2 B:ASP247 4.2 37.5 1.0
OE1 C:GLU312 4.3 17.6 1.0
CG B:GLU243 4.3 16.4 1.0
O B:HOH648 4.3 43.6 1.0
CG2 B:THR246 4.4 14.5 1.0
N B:ASP247 4.5 8.4 1.0
OG1 B:THR246 4.6 19.6 1.0
OE1 B:GLU138 4.9 51.3 1.0
C B:THR246 5.0 8.3 1.0
CA B:THR246 5.0 6.5 1.0
N B:LEU244 5.0 17.2 1.0

Magnesium binding site 8 out of 14 in 8tul

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Magnesium binding site 8 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 8 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg501

b:65.0
occ:1.00
 O B:HOH646 2.1 65.0 1.0
O B:HOH650 2.9 64.4 1.0
O B:HOH651 2.9 59.2 1.0
O C:HOH640 3.6 44.0 1.0
O C:HOH628 4.0 43.6 1.0
O C:HOH637 4.0 47.4 1.0
O C:HOH624 4.1 56.0 1.0
CD C:GLU293 4.3 62.3 1.0
CD2 B:LEU264 4.3 67.8 1.0
OE2 C:GLU297 4.4 44.9 1.0
OE1 C:GLU293 4.4 60.9 1.0
OE2 C:GLU293 4.4 60.9 1.0
OE1 B:GLU261 4.5 70.0 1.0
CG C:GLU293 4.7 55.8 1.0
OE1 C:GLU297 4.8 47.1 1.0
CG B:LEU264 4.9 67.3 1.0

Magnesium binding site 9 out of 14 in 8tul

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Magnesium binding site 9 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 9 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg502

b:33.6
occ:1.00
 O C:HOH655 3.0 40.2 1.0
O C:GLU243 3.0 21.9 1.0
O C:HOH641 3.1 24.2 1.0
OE2 D:GLU312 3.3 23.4 1.0
OD1 C:ASP247 3.3 29.9 1.0
CA C:GLU243 3.6 5.3 1.0
CB C:GLU243 3.7 9.4 1.0
C C:GLU243 3.7 12.6 1.0
O D:HOH617 3.8 22.0 1.0
CB C:THR246 4.0 10.3 1.0
CG C:ASP247 4.0 31.6 1.0
CD D:GLU312 4.2 13.3 1.0
OD2 C:ASP247 4.2 37.5 1.0
OE1 D:GLU312 4.2 17.6 1.0
CG C:GLU243 4.3 16.4 1.0
O C:HOH648 4.3 43.6 1.0
CG2 C:THR246 4.4 14.5 1.0
N C:ASP247 4.5 8.4 1.0
OG1 C:THR246 4.6 19.6 1.0
OE1 C:GLU138 4.9 51.3 1.0
C C:THR246 5.0 8.3 1.0
CA C:THR246 5.0 6.5 1.0
N C:LEU244 5.0 17.2 1.0

Magnesium binding site 10 out of 14 in 8tul

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Magnesium binding site 10 out of 14 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 10 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+ Condition within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg503

b:30.0
occ:1.00
 OD2 D:ASP329 3.6 28.8 1.0
OD2 E:ASP329 3.7 28.8 1.0
OD2 C:ASP329 3.7 28.8 1.0
OD2 A:ASP329 3.8 28.8 1.0
OD2 B:ASP329 3.9 28.8 1.0
O A:HOH650 4.3 30.0 1.0
NH2 E:ARG332 4.4 0.0 1.0
NH2 D:ARG332 4.4 0.0 1.0
NH2 A:ARG332 4.5 0.0 1.0
NH2 C:ARG332 4.5 0.0 1.0
NH2 B:ARG332 4.6 0.0 1.0
CG D:ASP329 4.6 20.8 1.0
CG E:ASP329 4.7 20.8 1.0
CG C:ASP329 4.7 20.8 1.0
OD1 D:ASP329 4.8 18.6 1.0
CG A:ASP329 4.8 20.8 1.0
OD1 C:ASP329 4.8 18.6 1.0
CG B:ASP329 4.8 20.8 1.0
OD1 E:ASP329 4.9 18.6 1.0

Reference:

L.T.F.Lai, J.Balaraman, F.Zhou, D.Matthies. Cryo-Em Structures of Human Magnesium Channel MRS2 Reveal Gating and Regulatory Mechanisms. Biorxiv 2023.
ISSN: ISSN 2692-8205
PubMed: 37662257
DOI: 10.1101/2023.08.22.553867
Page generated: Fri Oct 4 20:57:11 2024

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