Magnesium in PDB 8tup: Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition

The binding sites of Magnesium atom in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition (pdb code 8tup). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition, PDB code: 8tup:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg501 b:30.0 occ:1.00 OD1 A:ASN339 3.7 11.8 1.0 OD1 D:ASN339 3.7 11.8 1.0 OD1 E:ASN339 3.7 11.8 1.0 OD1 B:ASN339 3.7 11.8 1.0 OD1 C:ASN339 3.7 11.8 1.0 CG A:ASN339 4.8 7.2 1.0 CG D:ASN339 4.8 7.2 1.0 CG E:ASN339 4.8 7.2 1.0 CG B:ASN339 4.8 7.2 1.0 CG C:ASN339 4.8 7.2 1.0

Magnesium binding site 2 out of 3 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg502 b:30.0 occ:1.00 OG1 A:THR346 4.9 23.1 1.0

Magnesium binding site 3 out of 3 in the Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of the Human MRS2 Magnesium Channel Under MG2+-Free Condition within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg501 b:30.0 occ:1.00 OD1 C:ASN362 3.6 36.6 1.0 OD1 B:ASN362 3.6 36.6 1.0 OD1 E:ASN362 3.6 36.6 1.0 OD1 D:ASN362 3.6 36.6 1.0 OD1 A:ASN362 3.7 36.6 1.0 O B:GLY360 3.9 35.9 1.0 O D:GLY360 3.9 35.9 1.0 O C:GLY360 3.9 35.9 1.0 O E:GLY360 3.9 35.9 1.0 O A:GLY360 3.9 35.9 1.0 CG C:ASN362 4.7 37.2 1.0 CG E:ASN362 4.7 37.2 1.0 CG B:ASN362 4.7 37.2 1.0 CG D:ASN362 4.7 37.2 1.0 CG A:ASN362 4.8 37.2 1.0 ND2 C:ASN362 4.9 34.4 1.0 ND2 E:ASN362 5.0 34.4 1.0 ND2 D:ASN362 5.0 34.4 1.0 ND2 B:ASN362 5.0 34.4 1.0

L.T.F.Lai, J.Balaraman, F.Zhou, D.Matthies. Cryo-Em Structures of Human Magnesium Channel MRS2 Reveal Gating and Regulatory Mechanisms. Biorxiv 2023.
ISSN: ISSN 2692-8205
PubMed: 37662257
DOI: 10.1101/2023.08.22.553867