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Atomistry » Magnesium » PDB 8tj0-8unh » 8txh | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 8tj0-8unh » 8txh » |
Magnesium in PDB 8txh: Crystal Structure of Kras G12D in Complex with Gdp and Compound 14Enzymatic activity of Crystal Structure of Kras G12D in Complex with Gdp and Compound 14
All present enzymatic activity of Crystal Structure of Kras G12D in Complex with Gdp and Compound 14:
3.6.5.2; Protein crystallography data
The structure of Crystal Structure of Kras G12D in Complex with Gdp and Compound 14, PDB code: 8txh
was solved by
P.Chen,
A.Irimia,
Z.Yang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8txh:
The structure of Crystal Structure of Kras G12D in Complex with Gdp and Compound 14 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Kras G12D in Complex with Gdp and Compound 14
(pdb code 8txh). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Kras G12D in Complex with Gdp and Compound 14, PDB code: 8txh: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 8txhGo back to Magnesium Binding Sites List in 8txh
Magnesium binding site 1 out
of 2 in the Crystal Structure of Kras G12D in Complex with Gdp and Compound 14
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 8txhGo back to Magnesium Binding Sites List in 8txh
Magnesium binding site 2 out
of 2 in the Crystal Structure of Kras G12D in Complex with Gdp and Compound 14
Mono view Stereo pair view
Reference:
H.Cheng,
P.Li,
P.Chen,
A.Irimia,
J.H.Bae,
A.Brooun,
P.Fagan,
R.Lam,
B.Lin,
J.Zhang,
X.Zhan,
X.Wu,
N.Xie,
G.Chiang,
R.Shoemaker,
J.M.Vernier.
Structure-Based Design and Synthesis of Potent and Selective Kras G12D Inhibitors. Acs Med.Chem.Lett. V. 14 1351 2023.
Page generated: Thu Dec 28 10:33:31 2023
ISSN: ISSN 1948-5875 PubMed: 37849557 DOI: 10.1021/ACSMEDCHEMLETT.3C00245 |
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