Magnesium in PDB 8u1m: Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State

The binding sites of Magnesium atom in the Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State (pdb code 8u1m). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State, PDB code: 8u1m:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:175.0 occ:1.00 O2G A:ATP801 1.9 176.3 1.0 O2B A:ATP801 2.0 176.3 1.0 O2A A:ATP801 2.0 176.3 1.0 O3A A:ATP801 2.2 176.3 1.0 PB A:ATP801 2.3 176.3 1.0 PA A:ATP801 2.3 176.3 1.0 NH2 A:ARG391 2.4 178.0 1.0 O3B A:ATP801 2.6 176.3 1.0 PG A:ATP801 2.9 176.3 1.0 ND2 A:ASN46 3.0 174.3 1.0 O5' A:ATP801 3.3 176.3 1.0 CZ A:ARG391 3.4 178.0 1.0 OE1 A:GLU42 3.6 175.6 1.0 O1B A:ATP801 3.7 176.3 1.0 O1G A:ATP801 3.7 176.3 1.0 CA A:GLY132 3.8 185.4 1.0 O1A A:ATP801 3.8 176.3 1.0 N A:GLY132 3.9 185.4 1.0 CG A:ASN46 3.9 174.3 1.0 OD1 A:ASN46 4.0 174.3 1.0 O3G A:ATP801 4.0 176.3 1.0 NE A:ARG391 4.1 178.0 1.0 NH1 A:ARG391 4.2 178.0 1.0 N A:PHE133 4.3 194.3 1.0 C A:GLY132 4.4 185.4 1.0 C5' A:ATP801 4.5 176.3 1.0 C3' A:ATP801 4.8 176.3 1.0 CD A:GLU42 4.8 175.6 1.0 O3' A:ATP801 4.8 176.3 1.0 CA A:GLY127 4.9 215.1 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the HSP90 Dimer (Ntd-Md) in the Semi-Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg802 b:229.9 occ:1.00 O3A B:ATP801 2.0 229.3 1.0 O3G B:ATP801 2.2 229.3 1.0 CG B:ASN46 2.2 227.8 1.0 ND2 B:ASN46 2.3 227.8 1.0 O2G B:ATP801 2.4 229.3 1.0 O2A B:ATP801 2.5 229.3 1.0 OD1 B:ASN46 2.5 227.8 1.0 PA B:ATP801 2.6 229.3 1.0 PG B:ATP801 2.6 229.3 1.0 O B:GLU42 2.9 211.7 1.0 CB B:ASN46 3.0 227.8 1.0 O3B B:ATP801 3.2 229.3 1.0 O5' B:ATP801 3.3 229.3 1.0 PB B:ATP801 3.3 229.3 1.0 CA B:ASN46 3.7 227.8 1.0 N B:ASN46 3.7 227.8 1.0 C B:GLU42 3.8 211.7 1.0 C5' B:ATP801 3.8 229.3 1.0 O1G B:ATP801 4.0 229.3 1.0 O1A B:ATP801 4.0 229.3 1.0 O2B B:ATP801 4.1 229.3 1.0 O1B B:ATP801 4.2 229.3 1.0 O4' B:ATP801 4.4 229.3 1.0 CA B:GLU42 4.5 211.7 1.0 CB B:GLU42 4.6 211.7 1.0 N B:LEU43 4.6 222.8 1.0 C B:SER45 4.7 225.4 1.0 CA B:LEU43 4.8 222.8 1.0 C4' B:ATP801 4.8 229.3 1.0 NH2 B:ARG391 4.9 184.2 1.0

L.I.Finci, M.Chakrabarti, G.Gulten, J.Finney, C.Grose, T.Fox, R.Yang, D.V.Nissley, F.Mccormick, D.Esposito, T.E.Balius, D.K.Simanshu. Structural Dynamics of RAF1-HSP90-CDC37 and HSP90 Complexes Reveal Asymmetric Client Interactions and Key Structural Elements. Commun Biol V. 7 260 2024.
ISSN: ESSN 2399-3642
PubMed: 38431713
DOI: 10.1038/S42003-024-05959-3