Magnesium in PDB 8u1n: Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State

The binding sites of Magnesium atom in the Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State (pdb code 8u1n). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State, PDB code: 8u1n:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:87.5 occ:1.00 O2G A:ATP801 1.9 98.3 1.0 O2B A:ATP801 1.9 98.3 1.0 O3B A:ATP801 2.3 98.3 1.0 PG A:ATP801 2.3 98.3 1.0 PB A:ATP801 2.3 98.3 1.0 O3G A:ATP801 2.5 98.3 1.0 O2A A:ATP801 2.8 98.3 1.0 ND2 A:ASN46 2.8 96.5 1.0 O3A A:ATP801 2.9 98.3 1.0 PA A:ATP801 3.3 98.3 1.0 CG A:ASN46 3.8 96.5 1.0 O1G A:ATP801 3.8 98.3 1.0 O1B A:ATP801 3.8 98.3 1.0 O5' A:ATP801 4.0 98.3 1.0 OD1 A:ASN46 4.1 96.5 1.0 CA A:GLY127 4.7 122.4 1.0 O1A A:ATP801 4.8 98.3 1.0 CA A:GLY132 4.8 110.4 1.0 O A:PHE129 4.8 114.8 1.0 N A:PHE133 4.9 98.7 1.0 CB A:ASN46 5.0 96.5 1.0 N A:GLY132 5.0 110.4 1.0 O A:GLU42 5.0 109.5 1.0

Magnesium binding site 2 out of 2 in the Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Cross-Linked HSP90 Dimer (Ntd-Md) in the Semi-Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg802 b:101.5 occ:1.00 O5' B:ATP801 1.9 99.7 1.0 O2A B:ATP801 1.9 99.7 1.0 O2G B:ATP801 2.0 99.7 1.0 O3G B:ATP801 2.0 99.7 1.0 PG B:ATP801 2.2 99.7 1.0 C5' B:ATP801 2.3 99.7 1.0 PA B:ATP801 2.4 99.7 1.0 O3B B:ATP801 2.7 99.7 1.0 O3A B:ATP801 2.8 99.7 1.0 C4' B:ATP801 3.4 99.7 1.0 ND2 B:ASN46 3.4 100.8 1.0 PB B:ATP801 3.5 99.7 1.0 O1A B:ATP801 3.5 99.7 1.0 CB B:ASN46 3.5 100.8 1.0 O4' B:ATP801 3.6 99.7 1.0 O1G B:ATP801 3.7 99.7 1.0 CG B:ASN46 3.9 100.8 1.0 C3' B:ATP801 4.4 99.7 1.0 O1B B:ATP801 4.4 99.7 1.0 O2B B:ATP801 4.5 99.7 1.0 N B:PHE133 4.5 86.5 1.0 CB B:PHE133 4.5 86.5 1.0 CA B:ASN46 4.8 100.8 1.0 CA B:PHE133 4.8 86.5 1.0 C B:GLY132 4.9 94.2 1.0 C1' B:ATP801 4.9 99.7 1.0

L.I.Finci, M.Chakrabarti, G.Gulten, J.Finney, C.Grose, T.Fox, R.Yang, D.V.Nissley, F.Mccormick, D.Esposito, T.E.Balius, D.K.Simanshu. Structural Dynamics of RAF1-HSP90-CDC37 and HSP90 Complexes Reveal Asymmetric Client Interactions and Key Structural Elements. Commun Biol V. 7 260 2024.
ISSN: ESSN 2399-3642
PubMed: 38431713
DOI: 10.1038/S42003-024-05959-3