Magnesium in PDB 8utt: KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule

The binding sites of Magnesium atom in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule (pdb code 8utt). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule, PDB code: 8utt:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule within 5.0Å range: probe atom residue distance (Å) B Occ K:Mg501 b:144.2 occ:1.00 O2G K:ANP502 1.2 137.8 1.0 PG K:ANP502 1.9 138.1 1.0 O3G K:ANP502 2.0 137.3 1.0 OG K:SER215 2.7 121.5 1.0 OG K:SER104 2.8 138.7 1.0 O1G K:ANP502 2.9 139.5 1.0 N3B K:ANP502 3.2 135.8 1.0 O2B K:ANP502 3.4 140.4 1.0 CB K:SER104 3.5 135.5 1.0 O2A K:ANP502 3.7 141.7 1.0 CB K:SER215 3.8 122.5 1.0 PB K:ANP502 3.9 143.5 1.0 N K:SER215 4.1 124.0 1.0 PA K:ANP502 4.3 146.3 1.0 O1A K:ANP502 4.4 140.0 1.0 N K:SER104 4.4 134.1 1.0 O3A K:ANP502 4.4 142.7 1.0 CA K:SER104 4.5 135.1 1.0 CA K:SER215 4.6 123.2 1.0 OD1 K:ASP248 4.7 130.3 1.0 C K:SER214 4.8 127.3 1.0 OD2 K:ASP248 4.8 128.9 1.0 CA K:SER214 4.9 128.1 1.0

Magnesium binding site 2 out of 4 in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg502 b:54.4 occ:1.00 O1G A:GTP501 1.9 81.2 1.0 O1B A:GTP501 2.0 80.9 1.0 OE2 A:GLU71 2.3 95.3 1.0 PG A:GTP501 3.2 82.5 1.0 PB A:GTP501 3.2 66.0 1.0 O3B A:GTP501 3.5 72.8 1.0 CD A:GLU71 3.5 99.3 1.0 O2B A:GTP501 3.8 86.2 1.0 OE1 A:GLN11 3.8 87.1 1.0 O3G A:GTP501 3.8 73.8 1.0 NZ B:LYS252 4.1 76.9 1.0 CB A:GLN11 4.2 68.6 1.0 O2G A:GTP501 4.3 89.7 1.0 OE1 A:GLU71 4.3 96.9 1.0 CG A:GLU71 4.4 97.7 1.0 O2A A:GTP501 4.5 78.8 1.0 O3A A:GTP501 4.5 68.8 1.0 OD2 A:ASP98 4.7 108.3 1.0 OD2 A:ASP69 4.7 98.8 1.0 ND2 B:ASN247 4.7 89.2 1.0 CD A:GLN11 4.8 77.4 1.0 OD1 A:ASP69 4.8 96.4 1.0 N A:GLN11 4.8 72.2 1.0

Magnesium binding site 3 out of 4 in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg502 b:85.2 occ:1.00 O1B E:GTP501 1.9 72.6 1.0 O3B E:GTP501 2.0 72.8 1.0 O1G E:GTP501 2.0 78.2 1.0 PG E:GTP501 2.3 84.3 1.0 PB E:GTP501 2.3 75.8 1.0 OD2 E:ASP98 2.3 103.4 1.0 O2G E:GTP501 3.0 85.3 1.0 CG E:ASP98 3.1 101.0 1.0 OD1 E:ASP98 3.1 106.0 1.0 O2B E:GTP501 3.2 87.0 1.0 OE1 E:GLU71 3.4 94.1 1.0 O3A E:GTP501 3.6 64.9 1.0 O3G E:GTP501 3.7 83.4 1.0 OG1 E:THR145 4.1 83.2 1.0 CB E:THR145 4.3 75.8 1.0 CD E:GLU71 4.3 100.3 1.0 CB E:ASP98 4.5 87.2 1.0 CG E:GLU71 4.7 98.2 1.0 OD1 E:ASP69 4.7 96.0 1.0 N E:THR145 4.8 74.6 1.0

Magnesium binding site 4 out of 4 in the KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of KIF1A[1-393] P305L Mutant Amp-Pnp Bound Two-Heads-Bound State in Complex with A Microtubule within 5.0Å range: probe atom residue distance (Å) B Occ S:Mg502 b:139.6 occ:1.00 O1G S:GTP501 1.9 129.6 1.0 O1B S:GTP501 2.0 132.8 1.0 O3B S:GTP501 2.1 132.8 1.0 PB S:GTP501 2.3 133.0 1.0 OE1 S:GLU71 2.3 145.1 1.0 PG S:GTP501 2.5 134.1 1.0 O2B S:GTP501 2.9 131.4 1.0 CD S:GLU71 3.2 145.8 1.0 O2G S:GTP501 3.4 134.7 1.0 O3G S:GTP501 3.6 130.4 1.0 OG1 S:THR145 3.7 133.9 1.0 O3A S:GTP501 3.8 128.9 1.0 CG S:GLU71 3.9 144.6 1.0 OE2 S:GLU71 4.1 145.5 1.0 OD1 S:ASP69 4.3 137.5 1.0 OE1 S:GLN11 4.7 126.3 1.0 O2A S:GTP501 4.7 134.1 1.0 CB S:ASP98 4.7 145.7 1.0 CB S:GLN11 4.8 125.9 1.0 CG2 S:THR145 4.8 130.3 1.0 CB S:THR145 4.8 131.0 1.0 OD2 S:ASP98 4.9 145.9 1.0 N S:GLN11 4.9 124.3 1.0 OD2 S:ASP69 4.9 139.4 1.0 CB S:GLU71 4.9 143.8 1.0 PA S:GTP501 5.0 136.2 1.0

M.P.M.H.Benoit, L.Rao, A.B.Asenjo, A.Gennerich, H.Sosa. Cryo-Em of Human KIF1A Reveals Its Mechanism of Motility and the Effect of Its Pathogenic Variant P305L To Be Published.