Magnesium in PDB 9b4s: Crystal Structure of the RRAS2-P110ALPHA Complex

All present enzymatic activity of Crystal Structure of the RRAS2-P110ALPHA Complex:
2.7.1.137; 2.7.1.153; 2.7.11.1;

The structure of Crystal Structure of the RRAS2-P110ALPHA Complex, PDB code: 9b4s was solved by D.J.Czyzyk, D.K.Simanshu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.26 / 3.10
Space group	P 42 21 2
Cell size a, b, c (Å), α, β, γ (°)	181.488, 181.488, 96.03, 90, 90, 90
R / Rfree (%)	23 / 27.2

The binding sites of Magnesium atom in the Crystal Structure of the RRAS2-P110ALPHA Complex (pdb code 9b4s). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of the RRAS2-P110ALPHA Complex, PDB code: 9b4s:

Magnesium binding site 1 out of 1 in the Crystal Structure of the RRAS2-P110ALPHA Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the RRAS2-P110ALPHA Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg202 b:105.2 occ:1.00 O2B B:GNP201 1.9 115.2 1.0 OG1 B:THR46 2.0 118.7 1.0 OG B:SER28 2.1 101.1 1.0 O2G B:GNP201 2.3 112.4 1.0 CB B:THR46 2.7 94.3 1.0 PB B:GNP201 3.1 119.4 1.0 N3B B:GNP201 3.2 112.4 1.0 PG B:GNP201 3.2 109.8 1.0 CB B:SER28 3.4 125.6 1.0 OD2 B:ASP68 3.6 128.6 1.0 N B:THR46 3.6 134.5 1.0 O3G B:GNP201 3.7 127.3 1.0 CA B:THR46 3.7 108.7 1.0 CG2 B:THR46 3.8 94.4 1.0 OD1 B:ASP68 3.8 111.4 1.0 N B:SER28 4.0 140.1 1.0 O3A B:GNP201 4.0 136.4 1.0 CG B:ASP68 4.0 128.0 1.0 O B:ASP44 4.2 125.4 1.0 CA B:SER28 4.2 128.7 1.0 O B:THR69 4.2 121.5 1.0 O2A B:GNP201 4.2 145.0 1.0 CE B:LYS27 4.3 119.2 1.0 O1B B:GNP201 4.3 101.0 1.0 O1G B:GNP201 4.6 103.7 1.0 CB B:LYS27 4.6 119.0 1.0 PA B:GNP201 4.7 116.6 1.0 C B:THR46 4.8 91.3 1.0 C B:PRO45 4.8 119.8 1.0 C B:LYS27 4.8 144.1 1.0 NZ B:LYS27 4.9 119.8 1.0 O B:THR46 5.0 110.0 1.0

D.Czyzyk, W.Yan, S.Messing, W.Gillette, T.Tsuji, M.Yamaguchi, S.Furuzono, D.M.Turner, D.Esposito, D.V.Nissley, F.Mccormick, D.K.Simanshu. Structural Insights Into Isoform-Specific Ras-PI3K Alpha Interactions and the Role of Ras in PI3K Alpha Activation. Nat Commun V. 16 525 2025.
ISSN: ESSN 2041-1723
PubMed: 39788953
DOI: 10.1038/S41467-024-55766-X