Magnesium in PDB 9c48: Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State

The binding sites of Magnesium atom in the Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State (pdb code 9c48). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State, PDB code: 9c48:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in the Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg405 b:48.7 occ:1.00 OD2 A:ASP170 2.4 55.4 1.0 O2G C:ATP502 2.5 45.3 1.0 CG A:ASP170 3.1 55.4 1.0 OD1 A:ASP170 3.1 55.4 1.0 O A:HOH585 3.5 48.7 1.0 PG C:ATP502 3.7 45.3 1.0 O1G C:ATP502 3.7 45.3 1.0 O1B C:ATP502 3.8 45.3 1.0 NZ A:LYS313 3.8 41.3 1.0 O C:HOH643 3.9 58.6 1.0 NH2 A:ARG295 4.2 41.2 1.0 O C:HOH631 4.4 53.3 1.0 CB A:ASP170 4.5 55.4 1.0 O3B C:ATP502 4.6 45.3 1.0 PB C:ATP502 4.7 45.3 1.0 O3G C:ATP502 4.8 45.3 1.0 O A:ASP170 4.9 55.4 1.0

Magnesium binding site 2 out of 3 in the Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg501 b:48.7 occ:1.00 OD2 B:ASP170 2.4 55.4 1.0 O2G A:ATP401 2.5 45.3 1.0 CG B:ASP170 3.1 55.4 1.0 OD1 B:ASP170 3.1 55.4 1.0 O B:HOH682 3.5 55.8 1.0 PG A:ATP401 3.7 45.3 1.0 O1G A:ATP401 3.7 45.3 1.0 O1B A:ATP401 3.8 45.3 1.0 NZ B:LYS313 3.9 41.3 1.0 O A:HOH543 3.9 58.2 1.0 NH2 B:ARG295 4.2 41.2 1.0 O A:HOH529 4.4 51.6 1.0 CB B:ASP170 4.5 55.4 1.0 O3B A:ATP401 4.6 45.3 1.0 PB A:ATP401 4.7 45.3 1.0 O3G A:ATP401 4.8 45.3 1.0 O B:ASP170 4.9 55.4 1.0

Magnesium binding site 3 out of 3 in the Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of the Full-Length Human P2X4 Receptor in the Atp- Bound Desensitized State within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg501 b:48.7 occ:1.00 OD2 C:ASP170 2.4 55.4 1.0 O2G B:ATP502 2.5 45.3 1.0 CG C:ASP170 3.1 55.4 1.0 OD1 C:ASP170 3.1 55.4 1.0 O C:HOH682 3.4 52.5 1.0 PG B:ATP502 3.7 45.3 1.0 O1G B:ATP502 3.7 45.3 1.0 O1B B:ATP502 3.8 45.3 1.0 NZ C:LYS313 3.8 41.3 1.0 O B:HOH643 3.9 57.1 1.0 NH2 C:ARG295 4.2 41.2 1.0 O B:HOH632 4.4 51.6 1.0 CB C:ASP170 4.5 55.4 1.0 O3B B:ATP502 4.6 45.3 1.0 PB B:ATP502 4.7 45.3 1.0 O3G B:ATP502 4.8 45.3 1.0 O C:ASP170 4.9 55.4 1.0

H.Shi, I.A.Ditter, A.C.Oken, S.E.Mansoor. Human P2X4 Receptor Gating Is Modulated By A Stable Cytoplasmic Cap and A Unique Allosteric Pocket. Sci Adv V. 11 R3315 2025.
ISSN: ESSN 2375-2548
PubMed: 39823330
DOI: 10.1126/SCIADV.ADR3315