Magnesium in PDB 9cxh: Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp

All present enzymatic activity of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp:
3.1.4.35;

The structure of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Magnesium atom in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp (pdb code 9cxh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp, PDB code: 9cxh:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg903 b:62.1 occ:1.00 O2P A:5GP904 1.9 95.9 1.0 OD1 A:ASP603 2.5 82.0 1.0 P A:5GP904 3.1 111.0 1.0 O1P A:5GP904 3.3 116.4 1.0 CG A:ASP603 3.6 80.6 1.0 OE2 A:GLU631 3.7 100.3 1.0 NE2 A:HIS634 3.8 74.6 1.0 CD2 A:HIS634 3.9 67.3 1.0 O5' A:5GP904 3.9 104.5 1.0 CD2 A:HIS606 4.0 79.7 1.0 OD2 A:ASP603 4.0 74.5 1.0 NE2 A:HIS606 4.1 77.0 1.0 CG2 A:THR672 4.3 80.6 1.0 O3P A:5GP904 4.3 103.4 1.0 CD A:GLU631 4.4 95.2 1.0 O A:HIS602 4.5 85.9 1.0 CG A:GLU631 4.6 89.6 1.0 ZN A:ZN902 4.8 119.9 1.0 CB A:ASP603 4.9 75.1 1.0 CA A:ASP603 5.0 76.6 1.0

Magnesium binding site 2 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Presence of Cgmp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg903 b:54.0 occ:1.00 O1P B:5GP904 2.0 112.0 1.0 O2P B:5GP904 2.1 105.2 1.0 P B:5GP904 2.4 118.4 1.0 OD1 B:ASP603 2.5 83.2 1.0 OE2 B:GLU631 3.1 100.0 1.0 O5' B:5GP904 3.4 111.9 1.0 CG B:ASP603 3.6 80.2 1.0 O3P B:5GP904 3.7 96.1 1.0 OD2 B:ASP603 4.0 70.1 1.0 NE2 B:HIS634 4.1 82.3 1.0 CD2 B:HIS634 4.1 71.2 1.0 OG1 B:THR672 4.1 94.8 1.0 CD B:GLU631 4.2 96.2 1.0 ZN B:ZN902 4.5 134.4 1.0 O B:HIS602 4.5 92.9 1.0 CD2 B:HIS606 4.5 78.5 1.0 CB B:THR672 4.6 83.1 1.0 NE2 B:HIS606 4.7 77.8 1.0 OD2 B:ASP723 4.7 100.7 1.0 CG B:GLU631 4.7 92.9 1.0 C5' B:5GP904 4.7 96.0 1.0 CB B:ASP603 4.9 71.0 1.0

S.Singh, D.Srivastava, K.Boyd, N.Artemyev. Structural and Functional Dynamics of Human Cone Cgmp-Phosphodiesterase Important For Photopic Vision Proc.Natl.Acad.Sci.Usa 2025.
ISSN: ESSN 1091-6490