Magnesium in PDB 9cxi: Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp

All present enzymatic activity of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp:
3.1.4.35;

The structure of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Magnesium atom in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp (pdb code 9cxi). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp, PDB code: 9cxi:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg902 b:55.0 occ:1.00 OD2 A:ASP603 2.1 69.8 1.0 OD1 A:ASP603 2.2 76.5 1.0 CG A:ASP603 2.3 67.8 1.0 ZN A:ZN901 2.9 108.2 1.0 CB A:ASP603 3.5 49.3 1.0 OD2 A:ASP723 3.5 77.7 1.0 CG2 A:THR672 3.8 66.8 1.0 CA A:ASP603 4.1 43.5 1.0 CD2 A:HIS606 4.1 61.1 1.0 CD2 A:HIS602 4.3 56.7 1.0 NE2 A:HIS562 4.4 48.9 1.0 CG A:ASP723 4.4 71.9 1.0 NE2 A:HIS566 4.4 52.4 1.0 NE2 A:HIS602 4.4 55.9 1.0 OD1 A:ASP723 4.4 80.9 1.0 CD2 A:HIS562 4.5 57.9 1.0 NE2 A:HIS606 4.6 57.4 1.0 O A:HIS602 4.6 74.5 1.0 NE2 A:HIS634 4.7 47.1 1.0 N A:ASP603 4.7 53.3 1.0 CD2 A:HIS634 4.8 44.0 1.0 CE1 A:HIS562 4.8 51.6 1.0 C A:HIS602 4.9 52.2 1.0 OE2 A:GLU631 5.0 74.8 1.0

Magnesium binding site 2 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit in the Absence of Added Cgmp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg902 b:30.7 occ:1.00 OD1 B:ASP603 2.1 60.4 1.0 CG B:ASP603 3.1 51.9 1.0 OE2 B:GLU631 3.4 68.1 1.0 OD2 B:ASP603 3.4 50.5 1.0 OG1 B:THR672 4.2 66.1 1.0 ZN B:ZN901 4.3 116.4 1.0 NE2 B:HIS634 4.3 50.3 1.0 O B:HIS602 4.3 56.4 1.0 CD2 B:HIS634 4.3 49.2 1.0 CD2 B:HIS602 4.4 52.9 1.0 CD2 B:HIS606 4.4 53.3 1.0 CB B:ASP603 4.4 37.8 1.0 CD B:GLU631 4.6 67.1 1.0 NE2 B:HIS606 4.6 54.0 1.0 OD1 B:ASP723 4.7 77.9 1.0 CB B:THR672 4.7 55.5 1.0 NE2 B:HIS602 4.7 60.2 1.0 CA B:ASP603 4.8 50.2 1.0 CD2 B:HIS562 4.9 57.3 1.0 NE2 B:HIS562 4.9 52.2 1.0

S.Singh, D.Srivastava, K.Boyd, N.Artemyev. Structural and Functional Dynamics of Human Cone Cgmp-Phosphodiesterase Important For Photopic Vision Proc.Natl.Acad.Sci.Usa 2025.
ISSN: ESSN 1091-6490