Magnesium in PDB 9cxj: Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region

All present enzymatic activity of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region:
3.1.4.35;

The structure of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Magnesium atom in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region (pdb code 9cxj). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region, PDB code: 9cxj:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg902 b:49.3 occ:1.00 OD1 A:ASP603 2.1 65.6 1.0 OD2 A:ASP603 2.1 69.0 1.0 CG A:ASP603 2.3 62.4 1.0 ZN A:ZN901 3.1 105.5 1.0 CB A:ASP603 3.8 43.5 1.0 OD1 A:ASP723 4.1 66.0 1.0 OE2 A:GLU631 4.2 79.1 1.0 CD2 A:HIS602 4.3 43.2 1.0 OD2 A:ASP723 4.4 72.0 1.0 CD2 A:HIS606 4.4 58.5 1.0 NE2 A:HIS566 4.4 65.5 1.0 NE2 A:HIS602 4.5 46.4 1.0 O A:HIS602 4.5 65.0 1.0 NE2 A:HIS562 4.6 65.6 1.0 CG A:ASP723 4.7 64.9 1.0 CE1 A:HIS562 4.7 69.2 1.0 CA A:ASP603 4.7 52.0 1.0 NE2 A:HIS606 4.7 57.1 1.0 NE2 A:HIS634 4.9 48.0 1.0 CD2 A:HIS634 5.0 46.5 1.0

Magnesium binding site 2 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg902 b:41.1 occ:1.00 OD1 B:ASP603 2.1 65.3 1.0 CG B:ASP603 2.9 63.8 1.0 OD2 B:ASP603 3.1 68.9 1.0 OE2 B:GLU631 3.2 79.3 1.0 ZN B:ZN901 3.7 116.1 1.0 OD2 B:ASP723 3.9 78.0 1.0 CB B:ASP603 4.3 44.1 1.0 CD B:GLU631 4.3 75.5 1.0 CD2 B:HIS606 4.3 58.7 1.0 CD2 B:HIS562 4.5 59.9 1.0 NE2 B:HIS606 4.5 56.2 1.0 OG1 B:THR672 4.5 68.3 1.0 NE2 B:HIS634 4.5 50.1 1.0 CD2 B:HIS634 4.6 47.7 1.0 NE2 B:HIS562 4.6 65.8 1.0 O B:HIS602 4.7 61.2 1.0 CD2 B:HIS602 4.7 41.7 1.0 O B:THR672 4.8 65.9 1.0 CG B:GLU631 4.8 67.6 1.0 CB B:THR672 4.9 59.4 1.0 CA B:ASP603 4.9 50.3 1.0 NE2 B:HIS602 5.0 45.1 1.0

S.Singh, D.Srivastava, K.Boyd, N.Artemyev. Structural and Functional Dynamics of Human Cone Cgmp-Phosphodiesterase Important For Photopic Vision Proc.Natl.Acad.Sci.Usa 2025.
ISSN: ESSN 1091-6490