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Magnesium in PDB 1aax: Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules

Enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules

All present enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules, PDB code: 1aax was solved by Y.A.Puius, Y.Zhao, M.Sullivan, D.Lawrence, S.C.Almo, Z.-Y.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.00 / 1.90
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 88.369, 88.369, 104.532, 90.00, 90.00, 120.00
R / Rfree (%) 18.2 / n/a

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules (pdb code 1aax). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules, PDB code: 1aax:

Magnesium binding site 1 out of 1 in 1aax

Go back to Magnesium Binding Sites List in 1aax
Magnesium binding site 1 out of 1 in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with Two Bis(Para-Phosphophenyl)Methane (Bppm) Molecules within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg401

b:38.7
occ:1.00
O A:HOH731 2.0 37.9 1.0
O A:HOH729 2.1 36.2 1.0
O A:HOH732 2.1 36.0 1.0
O A:HOH728 2.1 36.6 1.0
O A:HOH733 2.1 33.9 1.0
O A:HOH730 2.1 38.6 1.0
O A:HOH605 4.0 38.6 1.0
OE1 A:GLU130 4.0 23.3 1.0
OE2 A:GLU130 4.1 22.1 1.0
O A:HOH626 4.5 34.4 1.0
OE1 A:GLU129 4.5 24.6 1.0
O A:HOH719 4.5 41.5 1.0
CD A:GLU130 4.5 22.9 1.0
O A:HOH636 4.9 32.8 1.0

Reference:

Y.A.Puius, Y.Zhao, M.Sullivan, D.S.Lawrence, S.C.Almo, Z.Y.Zhang. Identification of A Second Aryl Phosphate-Binding Site in Protein-Tyrosine Phosphatase 1B: A Paradigm For Inhibitor Design. Proc.Natl.Acad.Sci.Usa V. 94 13420 1997.
ISSN: ISSN 0027-8424
PubMed: 9391040
DOI: 10.1073/PNAS.94.25.13420
Page generated: Mon Dec 14 03:30:03 2020

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