Magnesium in PDB 1b38: Human Cyclin-Dependent Kinase 2

All present enzymatic activity of Human Cyclin-Dependent Kinase 2:
2.7.1.37;

The structure of Human Cyclin-Dependent Kinase 2, PDB code: 1b38 was solved by N.R.Brown, M.E.M.Noble, A.M.Lawrie, M.C.Morris, P.Tunnah, G.Divita, L.N.Johnson, J.A.Endicott, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	53.333, 71.122, 72.190, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 25

The binding sites of Magnesium atom in the Human Cyclin-Dependent Kinase 2 (pdb code 1b38). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Cyclin-Dependent Kinase 2, PDB code: 1b38:

Magnesium binding site 1 out of 1 in the Human Cyclin-Dependent Kinase 2


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Cyclin-Dependent Kinase 2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg382 b:15.5 occ:0.60 OD2 A:ASP145 2.0 23.6 1.0 O A:HOH412 2.1 23.0 1.0 OD1 A:ASN132 2.1 24.4 1.0 O2A A:ATP381 2.1 25.7 1.0 O1B A:ATP381 2.1 25.0 1.0 O2G A:ATP381 2.2 31.7 1.0 PA A:ATP381 3.2 28.4 1.0 CG A:ASP145 3.2 23.4 1.0 CG A:ASN132 3.2 24.1 1.0 PB A:ATP381 3.3 27.0 1.0 PG A:ATP381 3.4 34.0 1.0 O3A A:ATP381 3.6 28.0 1.0 O3B A:ATP381 3.7 30.7 1.0 ND2 A:ASN132 3.8 21.5 1.0 O5' A:ATP381 3.9 29.1 1.0 NZ A:LYS33 4.0 34.0 1.0 CB A:ASP145 4.0 18.4 1.0 O3G A:ATP381 4.1 34.1 1.0 OD1 A:ASP145 4.1 23.5 1.0 O A:GLN131 4.3 21.9 1.0 CB A:ASN132 4.5 20.7 1.0 CA A:ASN132 4.5 19.4 1.0 O1A A:ATP381 4.5 29.1 1.0 O2B A:ATP381 4.6 26.3 1.0 O1G A:ATP381 4.6 31.7 1.0 C A:GLN131 4.8 20.8 1.0 N A:ASN132 4.8 18.0 1.0 C2' A:ATP381 4.8 32.7 1.0 C8 A:ATP381 4.9 25.7 1.0 CB A:ALA144 4.9 14.9 1.0

N.R.Brown, M.E.Noble, A.M.Lawrie, M.C.Morris, P.Tunnah, G.Divita, L.N.Johnson, J.A.Endicott. Effects of Phosphorylation of Threonine 160 on Cyclin-Dependent Kinase 2 Structure and Activity. J.Biol.Chem. V. 274 8746 1999.
ISSN: ISSN 0021-9258
PubMed: 10085115
DOI: 10.1074/JBC.274.13.8746