Atomistry » Magnesium » PDB 1c5u-1cxz » 1c5u
Atomistry »
  Magnesium »
    PDB 1c5u-1cxz »
      1c5u »

Magnesium in PDB 1c5u: Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator

Enzymatic activity of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator

All present enzymatic activity of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator:
3.4.21.4;

Protein crystallography data

The structure of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator, PDB code: 1c5u was solved by B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 7.50 / 1.37
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 54.910, 54.910, 109.200, 90.00, 90.00, 120.00
R / Rfree (%) 18.1 / 19.5

Other elements in 1c5u:

The structure of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator (pdb code 1c5u). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator, PDB code: 1c5u:

Magnesium binding site 1 out of 1 in 1c5u

Go back to Magnesium Binding Sites List in 1c5u
Magnesium binding site 1 out of 1 in the Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structural Basis For Selectivity of A Small Molecule, S1-Binding, Sub- Micromolar Inhibitor of Urokinase Type Plasminogen Activator within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg263

b:21.5
occ:1.06
H1 A:HOH250 2.3 11.2 1.0
HA3 A:GLY197 2.4 9.5 1.0
HA3 A:GLY43 2.8 9.3 1.0
O A:SER139 2.8 11.4 1.0
HA3 A:GLY140 2.8 10.6 1.0
HA2 A:GLY140 2.8 10.8 1.0
O A:HOH250 2.9 12.7 1.0
HA A:ASP194 3.0 11.9 1.0
O A:ASP194 3.0 11.2 1.0
OE1 A:GLN30 3.2 15.2 1.0
CA A:GLY140 3.3 10.6 1.0
CA A:GLY197 3.3 9.5 1.0
HD2 A:PRO198 3.4 11.4 1.0
HE21 A:GLN30 3.5 13.8 1.0
H2 A:HOH250 3.6 11.0 1.0
HA2 A:GLY197 3.6 9.4 1.0
H A:GLY197 3.6 9.4 1.0
C A:SER139 3.7 11.9 1.0
C A:ASP194 3.7 11.4 1.0
CA A:ASP194 3.8 12.6 1.0
HB3 A:ASP194 3.8 11.9 1.0
CA A:GLY43 3.8 9.4 1.0
N A:GLY197 3.8 8.7 1.0
H A:TRP141 3.9 10.7 1.0
N A:GLY140 4.0 11.4 1.0
CD A:GLN30 4.0 13.8 1.0
NE2 A:GLN30 4.1 13.2 1.0
H A:GLY43 4.2 9.6 1.0
HG23 A:VAL213 4.3 8.8 1.0
CB A:ASP194 4.3 12.1 1.0
N A:GLY43 4.3 9.1 1.0
CD A:PRO198 4.3 10.9 1.0
HA2 A:GLY43 4.3 9.5 1.0
C A:GLY197 4.5 10.9 1.0
OD2 A:ASP194 4.5 13.5 1.0
HD3 A:PRO198 4.5 11.6 1.0
C A:GLY140 4.5 11.0 1.0
N A:TRP141 4.6 10.5 1.0
H A:GLY44 4.6 10.1 1.0
HE3 A:TRP141 4.6 13.4 1.0
O A:GLY193 4.7 13.4 1.0
C A:GLY43 4.7 8.3 1.0
O A:SER195 4.7 9.3 1.0
N A:PRO198 4.8 11.1 1.0
HE1 A:HIS40 4.8 13.7 1.0
CG A:ASP194 4.9 13.1 1.0
HD13 A:LEU155 4.9 11.6 1.0
N A:SER195 4.9 11.7 1.0
N A:GLY44 5.0 10.3 1.0
C A:GLY196 5.0 8.4 1.0
H A:GLY140 5.0 10.8 1.0
HE22 A:GLN30 5.0 13.5 1.0

Reference:

B.A.Katz, R.Mackman, C.Luong, K.Radika, A.Martelli, P.A.Sprengeler, J.Wang, H.Chan, L.Wong. Structural Basis For Selectivity of A Small Molecule, S1-Binding, Submicromolar Inhibitor of Urokinase-Type Plasminogen Activator. Chem.Biol. V. 7 299 2000.
ISSN: ISSN 1074-5521
PubMed: 10779411
DOI: 10.1016/S1074-5521(00)00104-6
Page generated: Tue Aug 13 02:27:57 2024

Last articles

Na in 2FM1
Na in 2FLD
Na in 2FJB
Na in 2FIR
Na in 2FI5
Na in 2FI4
Na in 2FI3
Na in 2F6D
Na in 2F81
Na in 2FAD
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy