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Magnesium in PDB 1cju: Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg

Enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg

All present enzymatic activity of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg:
4.6.1.1;

Protein crystallography data

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg, PDB code: 1cju was solved by J.J.G.Tesmer, S.R.Sprang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.80
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 118.300, 134.200, 71.400, 90.00, 90.00, 90.00
R / Rfree (%) 22.2 / 28.4

Other elements in 1cju:

The structure of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg (pdb code 1cju). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg, PDB code: 1cju:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in 1cju

Go back to Magnesium Binding Sites List in 1cju
Magnesium binding site 1 out of 3 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg581

b:53.6
occ:1.00
 O2A A:DAD102 2.2 41.7 1.0
O A:HOH57 2.2 26.1 1.0
OD1 A:ASP440 2.4 43.9 1.0
OD1 A:ASP396 2.5 49.9 1.0
PA A:DAD102 3.4 43.9 1.0
CG A:ASP440 3.4 43.4 1.0
CG A:ASP396 3.4 46.4 1.0
C5' A:DAD102 3.4 42.2 1.0
MG A:MG582 3.4 19.5 1.0
OD2 A:ASP396 3.6 47.2 1.0
OD2 A:ASP440 3.7 43.9 1.0
C4' A:DAD102 3.8 41.0 1.0
O5' A:DAD102 3.9 44.8 1.0
O4' A:DAD102 3.9 40.0 1.0
O1A A:DAD102 4.0 43.2 1.0
CB A:CYS441 4.2 41.0 1.0
N A:CYS441 4.4 40.9 1.0
O2G A:DAD102 4.4 44.3 1.0
O3A A:DAD102 4.6 46.1 1.0
O A:LEU438 4.6 35.3 1.0
O1B A:DAD102 4.7 46.3 1.0
CA A:CYS441 4.7 40.4 1.0
C A:ASP440 4.8 40.4 1.0
CB A:ASP440 4.8 41.6 1.0
CB A:ASP396 4.8 44.7 1.0
N A:ASP440 4.8 40.4 1.0

Magnesium binding site 2 out of 3 in 1cju

Go back to Magnesium Binding Sites List in 1cju
Magnesium binding site 2 out of 3 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg582

b:19.5
occ:1.00
 O2G A:DAD102 2.0 44.3 1.0
O1B A:DAD102 2.0 46.3 1.0
OD2 A:ASP396 2.2 47.2 1.0
O A:ILE397 2.2 45.1 1.0
OD2 A:ASP440 2.2 43.9 1.0
O2A A:DAD102 2.3 41.7 1.0
PB A:DAD102 3.1 46.6 1.0
CG A:ASP396 3.1 46.4 1.0
PG A:DAD102 3.2 46.5 1.0
CG A:ASP440 3.3 43.4 1.0
O3B A:DAD102 3.3 47.0 1.0
O3A A:DAD102 3.4 46.1 1.0
C A:ILE397 3.4 46.3 1.0
PA A:DAD102 3.4 43.9 1.0
OD1 A:ASP396 3.4 49.9 1.0
MG A:MG581 3.4 53.6 1.0
OD1 A:ASP440 3.6 43.9 1.0
O3G A:DAD102 3.9 47.0 1.0
N A:ILE397 4.0 45.3 1.0
O5' A:DAD102 4.1 44.8 1.0
CA A:ILE397 4.2 46.3 1.0
CB A:PHE400 4.2 43.4 1.0
N A:GLU398 4.4 47.3 1.0
O1G A:DAD102 4.4 44.6 1.0
CB A:ASP396 4.4 44.7 1.0
C5' A:DAD102 4.5 42.2 1.0
O2B A:DAD102 4.5 45.9 1.0
N A:PHE400 4.5 44.1 1.0
N A:GLY399 4.5 44.1 1.0
CA A:GLU398 4.6 47.7 1.0
CB A:ILE397 4.6 47.8 1.0
C A:ASP396 4.6 45.0 1.0
NH2 A:ARG484 4.6 42.1 1.0
CB A:ASP440 4.6 41.6 1.0
O1A A:DAD102 4.7 43.2 1.0
C A:GLU398 4.9 45.9 1.0

Magnesium binding site 3 out of 3 in 1cju

Go back to Magnesium Binding Sites List in 1cju
Magnesium binding site 3 out of 3 in the Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Complex of Gs-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Beta-L-2',3'-Dideoxyatp and Mg within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg403

b:2.0
occ:1.00
 O2G C:GSP405 1.7 29.6 1.0
O2B C:GSP405 2.0 27.0 1.0
O C:HOH415 2.0 18.7 1.0
OG C:SER54 2.1 22.3 1.0
O C:HOH412 2.2 2.0 1.0
OG1 C:THR204 2.3 35.9 1.0
PG C:GSP405 2.6 31.2 1.0
O3B C:GSP405 2.9 28.8 1.0
PB C:GSP405 3.0 26.4 1.0
CB C:THR204 3.2 34.3 1.0
CB C:SER54 3.2 26.2 1.0
O3G C:GSP405 3.3 29.9 1.0
N C:SER54 3.7 25.2 1.0
O1B C:GSP405 4.0 25.0 1.0
O3A C:GSP405 4.0 26.5 1.0
CA C:SER54 4.0 25.7 1.0
CG2 C:THR204 4.1 33.8 1.0
OD2 C:ASP223 4.2 36.7 1.0
O2A C:GSP405 4.3 26.9 1.0
N C:THR204 4.3 36.9 1.0
S1G C:GSP405 4.3 31.7 1.0
CA C:THR204 4.4 37.2 1.0
OD1 C:ASP223 4.4 40.6 1.0
O C:VAL224 4.4 26.7 1.0
PA C:GSP405 4.5 28.4 1.0
O1A C:GSP405 4.5 27.5 1.0
CB C:LYS53 4.6 25.4 1.0
CG C:ASP223 4.7 38.7 1.0
C C:LYS53 4.8 25.0 1.0
NZ C:LYS53 4.9 25.3 1.0
O C:VAL202 4.9 36.2 1.0

Reference:

J.J.Tesmer, R.K.Sunahara, R.A.Johnson, G.Gosselin, A.G.Gilman, S.R.Sprang. Two-Metal-Ion Catalysis in Adenylyl Cyclase. Science V. 285 756 1999.
ISSN: ISSN 0036-8075
PubMed: 10427002
DOI: 10.1126/SCIENCE.285.5428.756
Page generated: Tue Aug 13 02:29:07 2024

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