|
Atomistry » Magnesium » PDB 1e9b-1enn » 1e9e | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 1e9b-1enn » 1e9e » |
Magnesium in PDB 1e9e: Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and AdpEnzymatic activity of Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp
All present enzymatic activity of Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp:
2.7.4.9; Protein crystallography data
The structure of Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp, PDB code: 1e9e
was solved by
N.Ostermann,
A.Lavie,
S.Padiyar,
R.Brundiers,
T.Veit,
J.Reintein,
R.S.Goody,
M.Konrad,
I.Schlichting,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp
(pdb code 1e9e). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp, PDB code: 1e9e: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 1e9eGo back to![]() ![]()
Magnesium binding site 1 out
of 2 in the Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp
![]() Mono view ![]() Stereo pair view
Magnesium binding site 2 out of 2 in 1e9eGo back to![]() ![]()
Magnesium binding site 2 out
of 2 in the Mutant Human Thymidylate Kinase (F105Y) Complexed with Dtmp and Adp
![]() Mono view ![]() Stereo pair view
Reference:
N.Ostermann,
A.Lavie,
S.Padiyar,
R.Brundiers,
T.Veit,
J.Reintein,
R.S.Goody,
M.Konrad,
I.Schlichting.
Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons For the Mutants' Improved Kinetics with the Hiv Prodrug Metabolite Aztmp J.Mol.Biol. V. 304 43 2000.
Page generated: Tue Aug 13 02:53:24 2024
ISSN: ISSN 0022-2836 PubMed: 11071809 DOI: 10.1006/JMBI.2000.4175 |
Last articlesFe in 2YXOFe in 2YRS Fe in 2YXC Fe in 2YNM Fe in 2YVJ Fe in 2YP1 Fe in 2YU2 Fe in 2YU1 Fe in 2YQB Fe in 2YOO |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |