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Magnesium in PDB 1i0l: Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant

Enzymatic activity of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant

All present enzymatic activity of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant:
2.4.2.8;

Protein crystallography data

The structure of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant, PDB code: 1i0l was solved by B.Canyuk, P.J.Focia, A.E.Eakin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 1.72
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 39.570, 103.500, 52.150, 90.00, 93.94, 90.00
R / Rfree (%) 21 / 26.7

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant (pdb code 1i0l). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant, PDB code: 1i0l:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in 1i0l

Go back to Magnesium Binding Sites List in 1i0l
Magnesium binding site 1 out of 3 in the Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg902

b:21.4
occ:1.00
O1B A:PRP801 1.9 19.2 1.0
O2A A:PRP801 2.0 22.8 1.0
O A:HOH993 2.0 23.5 1.0
O A:HOH995 2.0 16.5 1.0
OD1 A:ASP171 2.0 19.3 1.0
O A:HOH994 2.1 22.8 1.0
CG A:ASP171 3.1 19.7 1.0
PA A:PRP801 3.2 23.9 1.0
PB A:PRP801 3.2 23.2 1.0
OD2 A:ASP171 3.5 20.6 1.0
O3A A:PRP801 3.6 25.1 1.0
O A:HOH941 4.0 39.8 1.0
O1 A:PRP801 4.0 28.4 1.0
NH2 A:ARG177 4.0 15.4 1.0
NH1 A:ARG177 4.0 16.7 1.0
C1 A:PRP801 4.1 32.4 1.0
O3B A:PRP801 4.1 19.3 1.0
O A:HOH982 4.1 45.4 1.0
O A:ASP171 4.2 17.1 1.0
O1A A:PRP801 4.2 24.4 1.0
O2B A:PRP801 4.3 21.5 1.0
N3 A:7HP800 4.3 22.9 1.0
O2 A:PRP801 4.3 43.6 1.0
CB A:ASP171 4.4 17.5 1.0
CZ A:ARG177 4.4 17.8 1.0
N A:ASP171 4.5 16.2 1.0
O A:HOH970 4.5 31.8 1.0
O A:HOH942 4.6 35.1 1.0
C A:ASP171 4.7 18.1 1.0
CA A:ASP171 4.8 18.5 1.0
C2 A:PRP801 4.8 36.1 1.0
C2 A:7HP800 5.0 20.5 1.0

Magnesium binding site 2 out of 3 in 1i0l

Go back to Magnesium Binding Sites List in 1i0l
Magnesium binding site 2 out of 3 in the Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg912

b:19.3
occ:1.00
O B:HOH975 2.0 20.8 1.0
O B:HOH976 2.1 19.2 1.0
OD1 B:ASP171 2.1 23.1 1.0
O B:HOH974 2.1 18.4 1.0
O2A B:PRP811 2.2 16.8 1.0
O1B B:PRP811 2.2 16.0 1.0
CG B:ASP171 3.1 23.0 1.0
PA B:PRP811 3.3 19.2 1.0
OD2 B:ASP171 3.3 22.6 1.0
PB B:PRP811 3.4 18.4 1.0
O3A B:PRP811 3.5 22.5 1.0
O1 B:PRP811 4.0 21.5 1.0
O B:ASP171 4.1 21.4 1.0
NH2 B:ARG177 4.1 18.4 1.0
C1 B:PRP811 4.3 22.8 1.0
NH1 B:ARG177 4.3 17.2 1.0
O B:HOH936 4.3 21.6 1.0
O3B B:PRP811 4.3 15.2 1.0
N3 B:7HP810 4.3 26.6 1.0
O B:HOH932 4.3 46.1 1.0
O2B B:PRP811 4.4 19.7 1.0
CB B:ASP171 4.5 20.8 1.0
O B:GLY83 4.5 35.7 1.0
O1A B:PRP811 4.5 21.4 1.0
CZ B:ARG177 4.6 16.6 1.0
N B:ASP171 4.6 18.5 1.0
CB B:TYR82 4.7 34.9 1.0
C B:ASP171 4.7 21.2 1.0
O2 B:PRP811 4.8 25.1 1.0
C2 B:7HP810 4.9 25.0 1.0
CA B:ASP171 4.9 18.0 1.0

Magnesium binding site 3 out of 3 in 1i0l

Go back to Magnesium Binding Sites List in 1i0l
Magnesium binding site 3 out of 3 in the Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Analysis of An Invariant Aspartic Acid in Hprts-Asparagine Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg910

b:20.5
occ:1.00
O B:HOH977 2.0 20.3 1.0
O3 B:PRP811 2.1 21.6 1.0
O B:HOH978 2.1 20.2 1.0
O2 B:PRP811 2.1 25.1 1.0
O3B B:PRP811 2.2 15.2 1.0
O1 B:PRP811 2.5 21.5 1.0
C3 B:PRP811 2.9 22.4 1.0
C2 B:PRP811 2.9 23.1 1.0
C1 B:PRP811 3.3 22.8 1.0
PB B:PRP811 3.3 18.4 1.0
O3A B:PRP811 3.4 22.5 1.0
PA B:PRP811 3.7 19.2 1.0
OE2 B:GLU111 3.9 27.2 1.0
OD1 B:ASP112 3.9 26.9 1.0
OE1 B:GLU111 3.9 29.9 1.0
C4 B:PRP811 4.0 21.7 1.0
O B:HOH942 4.1 27.8 1.0
O4 B:PRP811 4.2 21.1 1.0
O1B B:PRP811 4.2 16.0 1.0
N B:GLY53 4.2 19.3 1.0
O B:LEU51 4.3 20.7 1.0
O2B B:PRP811 4.4 19.7 1.0
CD B:GLU111 4.4 28.0 1.0
O B:VAL50 4.4 17.3 1.0
CA B:GLY53 4.4 18.6 1.0
O B:VAL79 4.6 28.1 1.0
O1A B:PRP811 4.6 21.4 1.0
CG1 B:VAL50 4.7 19.0 1.0
N B:LYS52 4.7 19.0 1.0
C B:LEU51 4.7 19.5 1.0
O2A B:PRP811 4.7 16.8 1.0
CG B:ASP112 4.8 29.7 1.0
OD2 B:ASP112 4.8 33.5 1.0
O B:HOH976 5.0 19.2 1.0

Reference:

B.Canyuk, P.J.Focia, A.E.Eakin. The Role For An Invariant Aspartic Acid in Hypoxanthine Phosphoribosyltransferases Is Examined Using Saturation Mutagenesis, Functional Analysis, and X-Ray Crystallography. Biochemistry V. 40 2754 2001.
ISSN: ISSN 0006-2960
PubMed: 11258886
DOI: 10.1021/BI001195Q
Page generated: Tue Aug 13 04:33:25 2024

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