Magnesium in PDB 1n6q: Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N)

All present enzymatic activity of Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N):
2.7.7.49;

The structure of Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N), PDB code: 1n6q was solved by S.G.Sarafianos, A.D.Clark Jr., K.Das, S.Tuske, J.J.Birktoft, I.Ilankumaran, A.R.Ramesha, J.M.Sayer, D.M.Jerina, P.L.Boyer, S.H.Hughes, E.Arnold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.00
Space group	P 32 1 2
Cell size a, b, c (Å), α, β, γ (°)	166.350, 166.350, 220.960, 90.00, 90.00, 120.00
R / Rfree (%)	24.7 / 28.4

The binding sites of Magnesium atom in the Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N) (pdb code 1n6q). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N), PDB code: 1n6q:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1002 b:58.2 occ:1.00 OD2 A:ASP186 2.6 69.3 1.0 OD2 A:ASP110 2.7 99.6 1.0 OD1 A:ASP110 3.1 0.8 1.0 CG A:ASP110 3.1 99.0 1.0 CG A:ASP186 3.8 69.3 1.0 O A:HOH1003 4.4 51.2 1.0 OD1 A:ASP186 4.4 69.0 1.0 OP1 P:DA822 4.4 75.9 1.0 O A:LEU228 4.4 65.9 1.0 CB A:ASP110 4.5 96.5 1.0 O A:LEU109 4.7 82.0 1.0 NE2 A:HIS221 4.9 0.8 1.0 CB A:ASP186 4.9 69.3 1.0 CG1 A:VAL108 5.0 62.1 1.0

Magnesium binding site 2 out of 2 in the Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Hiv-1 Reverse Transcriptase Crosslinked to Pre- Translocation Aztmp-Terminated Dna (Complex N) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1001 b:54.7 occ:1.00 OD2 A:ASP498 2.4 61.0 1.0 OD1 A:ASP443 3.0 64.4 1.0 OE1 A:GLU478 3.0 60.1 1.0 CG A:ASP498 3.5 61.7 1.0 CB A:ALA538 3.6 62.3 1.0 OE2 A:GLU478 3.7 56.7 1.0 NE2 A:HIS539 3.7 94.9 1.0 CD A:GLU478 3.8 59.2 1.0 CG A:ASP443 3.9 62.2 1.0 OD2 A:ASP443 4.0 61.7 1.0 OD1 A:ASP498 4.1 60.4 1.0 OD1 A:ASP549 4.3 92.1 1.0 OP1 T:DC723 4.4 97.9 1.0 CD2 A:HIS539 4.4 95.0 1.0 CE1 A:HIS539 4.7 95.5 1.0 CB A:ASP498 4.7 61.4 1.0 O A:GLY444 4.7 72.4 1.0 O A:HOH1004 4.9 33.8 1.0

S.G.Sarafianos, A.D.Clark Jr., K.Das, S.Tuske, J.J.Birktoft, I.Ilankumaran, A.R.Ramesha, J.M.Sayer, D.M.Jerina, P.L.Boyer, S.H.Hughes, E.Arnold. Structures of Hiv-1 Reverse Transcriptase with Pre- and Post-Translocation Aztmp-Terminated Dna Embo J. V. 21 6614 2002.
ISSN: ISSN 0261-4189
PubMed: 12456667
DOI: 10.1093/EMBOJ/CDF637