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Magnesium in PDB 1nug: Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form)

Enzymatic activity of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form)

All present enzymatic activity of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form):
2.3.2.13;

Protein crystallography data

The structure of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form), PDB code: 1nug was solved by B.Ahvazi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.40
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 57.510, 66.810, 116.530, 97.24, 90.28, 98.36
R / Rfree (%) 19.4 / 24.8

Other elements in 1nug:

The structure of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form) also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Calcium (Ca) 4 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form) (pdb code 1nug). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form), PDB code: 1nug:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 1nug

Go back to Magnesium Binding Sites List in 1nug
Magnesium binding site 1 out of 2 in the Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg705

b:41.3
occ:1.00
 OD2 A:ASP303 2.2 38.4 1.0
OD2 A:ASP301 2.2 32.2 1.0
O A:SER307 2.5 27.3 1.0
OD1 A:ASN305 2.6 33.6 1.0
O A:HOH1013 2.6 47.1 1.0
O A:HOH993 2.9 48.5 1.0
CG A:ASP303 3.2 37.7 1.0
CG A:ASP301 3.4 32.4 1.0
CG A:ASN305 3.5 33.3 1.0
OD1 A:ASP303 3.6 37.7 1.0
C A:SER307 3.7 27.4 1.0
ND2 A:ASN305 3.8 33.4 1.0
N A:ASP303 3.9 35.8 1.0
N A:THR302 3.9 34.0 1.0
OD1 A:ASP301 4.1 32.2 1.0
CA A:ASP301 4.2 32.1 1.0
CB A:ASP303 4.4 37.0 1.0
CB A:ASP301 4.4 32.2 1.0
CA A:ASP303 4.5 36.3 1.0
C A:ASP301 4.5 33.0 1.0
O A:HOH1105 4.5 24.3 1.0
N A:SER307 4.5 28.1 1.0
C A:ASP303 4.6 36.4 1.0
CA A:SER307 4.6 27.7 1.0
N A:VAL308 4.6 27.1 1.0
CA A:VAL308 4.6 26.9 1.0
C A:THR302 4.7 35.3 1.0
OG1 A:THR302 4.7 35.1 1.0
N A:ASN305 4.7 34.1 1.0
CB A:ASN305 4.8 33.1 1.0
CA A:THR302 4.8 34.8 1.0
O A:ASP303 4.9 36.5 1.0
N A:ARG304 4.9 36.4 1.0
CG2 A:VAL308 4.9 27.3 1.0
CB A:SER307 5.0 27.9 1.0

Magnesium binding site 2 out of 2 in 1nug

Go back to Magnesium Binding Sites List in 1nug
Magnesium binding site 2 out of 2 in the Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (2 Calciums, 1 Mg, Inactive Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg705

b:48.1
occ:1.00
 O B:SER307 2.1 33.1 1.0
OD2 B:ASP303 2.4 43.1 1.0
OD2 B:ASP301 2.4 36.9 1.0
OD1 B:ASN305 2.9 38.4 1.0
CG B:ASP303 3.3 42.5 1.0
C B:SER307 3.4 33.2 1.0
O B:HOH984 3.4 23.2 1.0
CG B:ASP301 3.5 36.9 1.0
OD1 B:ASP303 3.6 42.5 1.0
CG B:ASN305 3.9 38.5 1.0
CA B:VAL308 4.0 31.8 1.0
N B:VAL308 4.1 32.5 1.0
ND2 B:ASN305 4.2 38.5 1.0
N B:THR302 4.2 38.9 1.0
OD1 B:ASP301 4.2 37.2 1.0
CA B:ASP301 4.2 36.8 1.0
N B:ASP303 4.3 41.0 1.0
CB B:ASP301 4.3 36.7 1.0
CA B:SER307 4.5 33.9 1.0
CB B:ASP303 4.5 42.0 1.0
C B:ASP301 4.6 37.8 1.0
N B:SER307 4.6 34.7 1.0
OD2 B:ASP309 4.6 30.5 1.0
CG1 B:VAL308 4.7 31.9 1.0
CA B:ASP303 4.8 41.5 1.0
C B:ASP303 4.9 41.6 1.0
C B:VAL308 4.9 31.3 1.0
CB B:SER307 4.9 33.9 1.0
OG B:SER307 5.0 34.4 1.0
N B:ASP309 5.0 30.5 1.0
CB B:VAL308 5.0 31.7 1.0

Reference:

B.Ahvazi, K.M.Boeshans, W.Idler, U.Baxa, P.M.Steinert. Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme J.Biol.Chem. V. 278 23834 2003.
ISSN: ISSN 0021-9258
PubMed: 12679341
DOI: 10.1074/JBC.M301162200
Page generated: Tue Aug 13 10:22:42 2024

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