Magnesium in PDB 1pa1: Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B

All present enzymatic activity of Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B:
3.1.3.48;

The structure of Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B, PDB code: 1pa1 was solved by Y.Romsicki, G.Scapin, V.Beaulieu-Audy, S.B.Patel, J.W.Becker, B.Kennedy, E.Asante-Appiah, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 1.60
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	88.451, 88.451, 104.356, 90.00, 90.00, 120.00
R / Rfree (%)	n/a / n/a

The structure of Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B also contains other interesting chemical elements:

Chlorine

(Cl)

6 atoms

The binding sites of Magnesium atom in the Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B (pdb code 1pa1). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B, PDB code: 1pa1:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg4000 b:16.8 occ:1.00 O A:HOH4001 2.0 17.9 1.0 O A:HOH4006 2.0 23.3 1.0 O A:HOH4004 2.0 24.6 1.0 O A:HOH4003 2.1 23.3 1.0 O A:HOH4005 2.1 24.8 1.0 O A:HOH4002 2.1 20.5 1.0 O A:HIS554 4.0 12.4 1.0 O A:HOH1153 4.3 20.4 1.0 O A:HOH1077 4.5 27.5 1.0 ND1 A:HIS554 4.6 12.9 1.0 O A:HOH1255 4.9 40.2 1.0 CB A:HIS554 4.9 12.3 1.0 C A:HIS554 4.9 12.1 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the C215D Mutant of Protein Tyrosine Phosphatase 1B within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg4010 b:33.6 occ:1.00 O A:HOH4011 1.9 36.8 1.0 O A:HOH4013 2.0 31.1 1.0 O A:HOH4016 2.2 40.6 1.0 O A:HOH4015 2.2 39.6 1.0 O A:HOH4014 2.3 39.5 1.0 O A:HOH4012 2.3 42.0 1.0 OE2 A:GLU659 4.0 19.6 0.5 O A:HOH1094 4.1 42.4 1.0 OE1 A:GLU661 4.1 26.7 1.0 NZ A:LYS641 4.2 29.3 1.0 OE2 A:GLU659 4.2 19.0 0.5 O A:HOH1210 4.5 32.0 1.0 OE1 A:GLU659 4.5 22.3 0.3 O A:HOH1215 4.6 38.9 1.0 CD A:GLU659 4.7 18.6 0.5 CE A:LYS641 4.8 28.6 1.0

Y.Romsicki, G.Scapin, V.Beaulieu-Audy, S.Patel, J.W.Becker, B.P.Kennedy, E.Asante-Appiah. Functional Characterization and Crystal Structure of the C215D Mutant of Protein-Tyrosine Phosphatase-1B J.Biol.Chem. V. 278 29009 2003.
ISSN: ISSN 0021-9258
PubMed: 12748196
DOI: 10.1074/JBC.M303817200