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Magnesium in PDB 1s6p: Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
Enzymatic activity of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
All present enzymatic activity of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943:
2.7.7.49;
2.7.7.49;
Protein crystallography data
The structure of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p
was solved by
K.Das,
E.Arnold,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.90 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 226.700, 67.400, 104.300, 90.00, 107.00, 90.00 |
| R / Rfree (%) | 24.5 / 31.2 |
Other elements in 1s6p:
The structure of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
(pdb code 1s6p). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p:
In total only one binding site of Magnesium was determined in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943, PDB code: 1s6p:
Magnesium binding site 1 out of 1 in 1s6p
Go back to
Magnesium Binding Sites List in 1s6p
Magnesium binding site 1 out
of 1 in the Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Rt) in Complex with Janssen-R100943 within 5.0Å range:
|
Reference:
K.Das,
A.D.Clark Jr.,
P.Lewi,
J.Heeres,
M.Dejonge,
L.Koymans,
H.Vinkers,
F.Daeyaert,
D.W.Ludovici,
M.J.Kukla,
B.Decorte,
R.W.Kavash,
C.Y.Ho,
H.Ye,
M.Lichtenstein,
K.Andries,
R.Pauwles,
M.-P.Debethune,
P.L.Boyer,
P.Clark,
S.H.Hughes,
P.A.Janssen,
E.Arnold.
Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-Nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective Against Wild-Type and Drug-Resistant Hiv-1 Variants J.Med.Chem. V. 47 2550 2004.
ISSN: ISSN 0022-2623
PubMed: 15115397
DOI: 10.1021/JM030558S
Page generated: Tue Aug 13 13:16:31 2024
ISSN: ISSN 0022-2623
PubMed: 15115397
DOI: 10.1021/JM030558S
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