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Magnesium in PDB 1s9i: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp
Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp
All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp:
2.7.1.37;
2.7.1.37;
Protein crystallography data
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp, PDB code: 1s9i
was solved by
J.F.Ohren,
H.Chen,
A.Pavlovsky,
C.Whitehead,
C.Yan,
P.Mcconnell,
A.Delaney,
D.T.Dudley,
J.Sebolt-Leopold,
C.A.Hasemann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 14.40 / 3.20 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 161.888, 161.888, 122.986, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 29 / 36.4 |
Other elements in 1s9i:
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp also contains other interesting chemical elements:
| Fluorine | (F) | 6 atoms |
| Iodine | (I) | 2 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp
(pdb code 1s9i). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp, PDB code: 1s9i:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp, PDB code: 1s9i:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 1s9i
Go back to
Magnesium Binding Sites List in 1s9i
Magnesium binding site 1 out
of 2 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 1s9i
Go back to
Magnesium Binding Sites List in 1s9i
Magnesium binding site 2 out
of 2 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 2 (MEK2)in A Complex with Ligand and Mgatp within 5.0Å range:
|
Reference:
J.F.Ohren,
H.Chen,
A.Pavlovsky,
C.Whitehead,
E.Zhang,
P.Kuffa,
C.Yan,
P.Mcconnell,
C.Spessard,
C.Banotai,
W.T.Mueller,
A.Delaney,
C.Omer,
J.Sebolt-Leopold,
D.T.Dudley,
I.K.Leung,
C.Flamme,
J.Warmus,
M.Kaufman,
S.Barrett,
H.Tecle,
C.A.Hasemann.
Structures of Human Map Kinase Kinase 1 (MEK1) and MEK2 Describe Novel Noncompetitive Kinase Inhibition. Nat.Struct.Mol.Biol. V. 11 1192 2004.
ISSN: ISSN 1545-9993
PubMed: 15543157
DOI: 10.1038/NSMB859
Page generated: Mon Dec 14 06:48:16 2020
ISSN: ISSN 1545-9993
PubMed: 15543157
DOI: 10.1038/NSMB859
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