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Magnesium in PDB 1t03: Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P)

Enzymatic activity of Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P)

All present enzymatic activity of Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P):
2.7.7.49;

Protein crystallography data

The structure of Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P), PDB code: 1t03 was solved by S.Tuske, S.G.Sarafianos, J.Ding, E.Arnold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 3.10
Space group P 32 1 2
Cell size a, b, c (Å), α, β, γ (°) 166.780, 166.780, 221.130, 90.00, 90.00, 120.00
R / Rfree (%) 25.6 / 29.5

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P) (pdb code 1t03). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P), PDB code: 1t03:

Magnesium binding site 1 out of 1 in 1t03

Go back to Magnesium Binding Sites List in 1t03
Magnesium binding site 1 out of 1 in the Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Reverse Transcriptase Crosslinked to Tenofovir Terminated Template-Primer (Complex P) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg559

b:18.8
occ:1.00
 OD2 A:ASP498 2.2 16.7 1.0
OE1 A:GLU478 2.6 14.1 1.0
OE2 A:GLU478 3.0 30.8 1.0
OD1 A:ASP443 3.0 60.8 1.0
CD A:GLU478 3.2 20.3 1.0
CG A:ASP498 3.4 36.9 1.0
O A:GLY444 3.7 46.4 1.0
CG A:ASP443 3.8 50.3 1.0
OD2 A:ASP443 3.8 66.2 1.0
OD1 A:ASP498 3.9 31.4 1.0
NE2 A:HIS539 4.0 91.1 1.0
CB A:ALA538 4.2 60.9 1.0
OP1 T:DC723 4.6 86.2 1.0
CB A:ASP498 4.6 36.3 1.0
CD2 A:HIS539 4.7 89.6 1.0
CG A:GLU478 4.8 14.5 1.0
C A:GLY444 4.9 47.5 1.0

Reference:

S.Tuske, S.G.Sarafianos, A.D.Clark Jr., J.Ding, L.K.Naeger, K.L.White, M.D.Miller, C.S.Gibbs, P.L.Boyer, P.Clark, G.Wang, B.L.Gaffney, R.A.Jones, D.M.Jerina, S.H.Hughes, E.Arnold. Structure of Hiv-1 Rt-Dna Complexes Before and After Incorporation of the Anti-Aids Drug Tenofovir Nat.Struct.Mol.Biol. V. 11 469 2004.
ISSN: ISSN 1545-9993
PubMed: 15107837
DOI: 10.1038/NSMB760
Page generated: Tue Aug 13 14:23:39 2024

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