Magnesium in PDB 1z2b: Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex

The structure of Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex, PDB code: 1z2b was solved by B.Gigant, C.Wang, R.B.G.Ravelli, F.Roussi, M.O.Steinmetz, P.A.Curmi, A.Sobel, M.Knossow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 4.10
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	324.852, 324.852, 54.208, 90.00, 90.00, 120.00
R / Rfree (%)	20.9 / 26.9

The binding sites of Magnesium atom in the Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex (pdb code 1z2b). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex, PDB code: 1z2b:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg500 b:0.8 occ:1.00 O3G A:GTP600 1.7 0.8 1.0 O2B A:GTP600 2.1 0.8 1.0 PG A:GTP600 2.6 0.8 1.0 O2G A:GTP600 2.7 0.8 1.0 N A:GLY144 3.0 0.8 1.0 CA A:GLY144 3.0 0.8 1.0 PB A:GTP600 3.0 0.8 1.0 CB A:ALA99 3.1 0.8 1.0 O3B A:GTP600 3.3 0.8 1.0 O3A A:GTP600 3.4 0.8 1.0 N A:THR145 3.5 0.8 1.0 N A:ASN101 3.7 0.8 1.0 C A:GLY144 3.8 0.8 1.0 OD1 A:ASP98 3.9 0.8 1.0 O1G A:GTP600 4.0 0.8 1.0 CG2 A:THR145 4.1 0.8 1.0 CA A:ASN101 4.1 0.8 1.0 CA A:ALA99 4.2 0.8 1.0 C A:GLY143 4.3 0.8 1.0 NZ B:LYS254 4.3 0.8 1.0 N A:ALA100 4.3 0.8 1.0 C A:ALA99 4.3 0.8 1.0 O1B A:GTP600 4.4 0.8 1.0 OD1 A:ASN101 4.5 0.8 1.0 N A:ALA99 4.6 0.8 1.0 CG A:ASN101 4.7 0.8 1.0 CA A:THR145 4.8 0.8 1.0 C A:ALA100 4.8 0.8 1.0 CA A:GLY143 4.9 0.8 1.0 O A:ALA99 4.9 0.8 1.0 PA A:GTP600 4.9 0.8 1.0 CB A:ASN101 4.9 0.8 1.0 CG A:ASP98 4.9 0.8 1.0 CE B:LYS254 5.0 0.8 1.0

Magnesium binding site 2 out of 2 in the Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Tubulin-Colchicine-Vinblastine: Stathmin-Like Domain Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg501 b:0.8 occ:1.00 O3G C:GTP601 1.7 0.8 1.0 O2B C:GTP601 1.8 0.8 1.0 PG C:GTP601 2.8 0.8 1.0 O2G C:GTP601 2.9 0.8 1.0 PB C:GTP601 3.0 0.8 1.0 CB C:ALA99 3.1 0.8 1.0 N C:GLY144 3.1 0.8 1.0 CA C:GLY144 3.1 0.8 1.0 N C:ASN101 3.5 0.8 1.0 O3B C:GTP601 3.5 0.8 1.0 O3A C:GTP601 3.5 0.8 1.0 NZ D:LYS254 3.6 0.8 1.0 OD1 C:ASP98 3.8 0.8 1.0 N C:THR145 3.8 0.8 1.0 CA C:ASN101 3.8 0.8 1.0 C C:GLY144 4.0 0.8 1.0 O1G C:GTP601 4.0 0.8 1.0 N C:ALA100 4.1 0.8 1.0 CA C:ALA99 4.2 0.8 1.0 O1B C:GTP601 4.2 0.8 1.0 CE D:LYS254 4.2 0.8 1.0 C C:ALA99 4.3 0.8 1.0 C C:GLY143 4.4 0.8 1.0 CG2 C:THR145 4.5 0.8 1.0 CG C:ASN101 4.5 0.8 1.0 OD1 C:ASN101 4.6 0.8 1.0 C C:ALA100 4.6 0.8 1.0 N C:ALA99 4.6 0.8 1.0 CB C:ASN101 4.6 0.8 1.0 PA C:GTP601 4.7 0.8 1.0 CG C:ASP98 4.8 0.8 1.0 O1A C:GTP601 4.8 0.8 1.0 CA C:ALA100 4.8 0.8 1.0 O C:ALA99 4.9 0.8 1.0 OD2 C:ASP98 4.9 0.8 1.0 CA C:GLY143 4.9 0.8 1.0 ND2 C:ASN101 5.0 0.8 1.0

B.Gigant, C.Wang, R.B.Ravelli, F.Roussi, M.O.Steinmetz, P.A.Curmi, A.Sobel, M.Knossow. Structural Basis For the Regulation of Tubulin By Vinblastine. Nature V. 435 519 2005.
ISSN: ISSN 0028-0836
PubMed: 15917812
DOI: 10.1038/NATURE03566