Magnesium in PDB 1z2p: Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3

The structure of Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3, PDB code: 1z2p was solved by G.J.Miller, M.P.Wilson, P.W.Majerus, J.H.Hurley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.35 / 1.22
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	38.237, 94.751, 47.361, 90.00, 110.40, 90.00
R / Rfree (%)	19.8 / 22.1

The binding sites of Magnesium atom in the Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3 (pdb code 1z2p). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3, PDB code: 1z2p:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3 within 5.0Å range: probe atom residue distance (Å) B Occ X:Mg1295 b:9.7 occ:1.00 O X:HOH1477 2.1 14.8 1.0 O2A X:ACP1476 2.1 8.4 1.0 O2G X:ACP1476 2.2 18.5 1.0 C3B X:ACP1476 2.2 11.7 1.0 OD2 X:ASP275 2.2 14.2 1.0 OD2 X:ASP289 2.3 9.3 1.0 PG X:ACP1476 2.8 23.0 1.0 CG X:ASP289 3.3 9.0 1.0 PA X:ACP1476 3.4 8.0 1.0 CG X:ASP275 3.5 11.7 1.0 PB X:ACP1476 3.5 9.6 1.0 CB X:ASP289 3.6 8.1 1.0 O1G X:ACP1476 3.7 18.3 1.0 O3A X:ACP1476 3.8 9.7 1.0 O1B X:ACP1476 3.9 10.4 1.0 O3G X:ACP1476 4.0 23.6 1.0 MG X:MG1296 4.0 10.6 1.0 OD1 X:ASP275 4.2 12.6 1.0 O3' X:ACP1476 4.2 9.9 1.0 ND2 X:ASN291 4.2 13.4 1.0 ND2 X:ASN210 4.3 17.7 1.0 OD1 X:ASP289 4.4 9.6 1.0 NZ X:LYS179 4.4 12.9 1.0 OP3 X:I3S500 4.4 31.7 1.0 CB X:ASP275 4.5 9.7 1.0 O1A X:ACP1476 4.5 8.4 1.0 O X:HOH1577 4.5 17.6 1.0 O5' X:ACP1476 4.5 8.0 1.0 C5' X:ACP1476 4.6 8.6 1.0 C3' X:ACP1476 4.7 8.8 1.0 O2B X:ACP1476 4.7 12.2 1.0 O X:HOH1720 4.8 36.5 1.0 OD1 X:ASN291 5.0 10.8 1.0 O6 X:I3S500 5.0 31.3 1.0

Magnesium binding site 2 out of 2 in the Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Inositol 1,3,4-Trisphosphate 5/6-Kinase in Complex with MG2+/Amp- Pcp/Ins(1,3,4)P3 within 5.0Å range: probe atom residue distance (Å) B Occ X:Mg1296 b:10.6 occ:1.00 O1B X:ACP1476 2.0 10.4 1.0 O X:HOH1479 2.0 12.1 1.0 O1G X:ACP1476 2.1 18.3 1.0 OD1 X:ASN291 2.1 10.8 1.0 OD2 X:ASP289 2.2 9.3 1.0 OD1 X:ASP289 2.4 9.6 1.0 CG X:ASP289 2.6 9.0 1.0 O X:HOH1478 2.6 23.7 1.0 CG X:ASN291 3.1 10.3 1.0 PB X:ACP1476 3.2 9.6 1.0 PG X:ACP1476 3.2 23.0 1.0 C3B X:ACP1476 3.5 11.7 1.0 ND2 X:ASN291 3.6 13.4 1.0 O2G X:ACP1476 3.9 18.5 1.0 MG X:MG1295 4.0 9.7 1.0 O6 X:I3S500 4.1 31.3 1.0 CB X:ASP289 4.1 8.1 1.0 O X:HOH1524 4.2 12.1 1.0 O3A X:ACP1476 4.3 9.7 1.0 O2B X:ACP1476 4.3 12.2 1.0 O5 X:I3S500 4.3 32.5 1.0 NH2 X:ARG94 4.3 9.8 1.0 O X:ALA140 4.3 13.5 1.0 O X:HOH1482 4.4 10.1 1.0 CB X:ASN291 4.5 9.5 1.0 O3G X:ACP1476 4.5 23.6 1.0 O X:HOH1821 4.7 24.0 1.0 O X:VAL290 4.7 8.2 1.0 O2A X:ACP1476 4.7 8.4 1.0 CE1 X:HIS147 4.8 16.7 1.0 PA X:ACP1476 4.9 8.0 1.0 C X:VAL290 5.0 7.8 1.0 CA X:ASN291 5.0 9.2 1.0 C6 X:I3S500 5.0 31.7 1.0

G.J.Miller, M.P.Wilson, P.W.Majerus, J.H.Hurley. Specificity Determinants in Inositol Polyphosphate Synthesis: Crystal Structure of Inositol 1,3,4-Trisphosphate 5/6-Kinase. Mol.Cell V. 18 201 2005.
ISSN: ISSN 1097-2765
PubMed: 15837423
DOI: 10.1016/J.MOLCEL.2005.03.016