Magnesium in PDB 1zd3: Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex

All present enzymatic activity of Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex:
3.3.2.3;

The structure of Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex, PDB code: 1zd3 was solved by G.A.Gomez, C.Morisseau, B.D.Hammock, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.30
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	92.410, 92.410, 243.316, 90.00, 90.00, 120.00
R / Rfree (%)	21.2 / 25.4

The binding sites of Magnesium atom in the Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex (pdb code 1zd3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex, PDB code: 1zd3:

Magnesium binding site 1 out of 1 in the Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg800 b:28.5 occ:1.00 O3 A:PO4900 2.0 83.8 1.0 OD2 A:ASP9 2.1 36.5 1.0 OD1 A:ASP185 2.2 38.5 1.0 O A:HOH721 2.4 46.3 1.0 O A:ASP11 2.4 35.6 1.0 CG A:ASP185 3.2 39.5 1.0 CG A:ASP9 3.3 35.7 1.0 P A:PO4900 3.4 84.1 1.0 OD2 A:ASP185 3.5 39.1 1.0 C A:ASP11 3.5 36.1 1.0 OD1 A:ASP184 3.7 40.8 1.0 OD1 A:ASP9 3.7 35.9 1.0 O4 A:PO4900 3.9 84.1 1.0 CB A:ASP11 4.0 36.3 1.0 CD1 A:ILE186 4.1 42.2 1.0 CA A:ASP11 4.2 35.7 1.0 O2 A:PO4900 4.3 84.7 1.0 O1 A:PO4900 4.3 84.0 1.0 CG1 A:ILE186 4.4 42.0 1.0 N A:ASP11 4.5 35.8 1.0 N A:ASP185 4.5 39.6 1.0 CB A:ASP9 4.5 34.9 1.0 CB A:ASP185 4.6 39.6 1.0 N A:GLY12 4.6 35.5 1.0 OD2 A:ASP11 4.6 35.5 1.0 CG A:ASP184 4.6 40.6 1.0 CA A:GLY12 4.8 35.4 1.0 CG A:ASP11 4.9 36.5 1.0 OD2 A:ASP184 5.0 40.3 1.0 N A:ILE186 5.0 40.6 1.0

G.A.Gomez, C.Morisseau, B.D.Hammock, D.W.Christianson. Human Soluble Epoxide Hydrolase: Structural Basis of Inhibition By 4-(3-Cyclohexylureido)-Carboxylic Acids Protein Sci. V. 15 58 2006.
ISSN: ISSN 0961-8368
PubMed: 16322563
DOI: 10.1110/PS.051720206