Atomistry » Magnesium » PDB 2amc-2b2k » 2aqx
Atomistry »
  Magnesium »
    PDB 2amc-2b2k »
      2aqx »

Magnesium in PDB 2aqx: Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B

Enzymatic activity of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B

All present enzymatic activity of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B:
2.7.1.127;

Protein crystallography data

The structure of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B, PDB code: 2aqx was solved by P.P.Chamberlain, M.L.Sandberg, K.Sauer, M.P.Cooke, S.A.Lesley, G.Spraggon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 53.204, 60.655, 56.851, 59.90, 72.74, 88.18
R / Rfree (%) 18.4 / 26.8

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B (pdb code 2aqx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B, PDB code: 2aqx:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 2aqx

Go back to Magnesium Binding Sites List in 2aqx
Magnesium binding site 1 out of 4 in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg600

b:17.6
occ:1.00
 O3G A:ATP1462 2.0 16.0 1.0
O2A A:ATP1462 2.0 23.2 1.0
O A:HOH105 2.2 17.5 1.0
OD2 A:ASP893 2.3 18.7 1.0
CG A:ASP893 3.1 20.1 1.0
CB A:ASP893 3.3 22.5 1.0
PA A:ATP1462 3.4 23.9 1.0
PG A:ATP1462 3.4 15.7 1.0
O A:GLY874 3.6 23.6 1.0
OG A:SER876 3.7 25.6 1.0
MG A:MG601 3.8 26.1 1.0
O3B A:ATP1462 3.9 18.1 1.0
O1B A:ATP1462 3.9 19.0 1.0
O1A A:ATP1462 4.0 23.6 1.0
O3A A:ATP1462 4.2 21.4 1.0
O1G A:ATP1462 4.2 13.3 1.0
CE A:LYS741 4.2 33.1 1.0
PB A:ATP1462 4.3 20.2 1.0
OD1 A:ASP893 4.3 19.2 1.0
O2G A:ATP1462 4.5 10.2 1.0
OD2 A:ASP739 4.5 27.9 1.0
O5' A:ATP1462 4.6 18.5 1.0
CB A:SER876 4.6 23.8 1.0
NZ A:LYS741 4.7 36.6 1.0
CA A:ASP893 4.8 23.0 1.0
C A:GLY874 4.8 22.7 1.0
CB A:ALA670 4.8 26.0 1.0
C5' A:ATP1462 5.0 21.4 1.0

Magnesium binding site 2 out of 4 in 2aqx

Go back to Magnesium Binding Sites List in 2aqx
Magnesium binding site 2 out of 4 in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg601

b:26.1
occ:1.00
 OD2 A:ASP893 1.9 18.7 1.0
O1G A:ATP1462 2.3 13.3 1.0
O1B A:ATP1462 2.4 19.0 1.0
OD1 A:ASP893 2.4 19.2 1.0
CG A:ASP893 2.4 20.1 1.0
PG A:ATP1462 3.2 15.7 1.0
O3G A:ATP1462 3.2 16.0 1.0
NZ A:LYS896 3.6 37.4 1.0
PB A:ATP1462 3.6 20.2 1.0
O3B A:ATP1462 3.8 18.1 1.0
MG A:MG600 3.8 17.6 1.0
CB A:ASP893 3.9 22.5 1.0
O A:GLY874 4.1 23.6 1.0
NZ A:LYS686 4.4 27.2 1.0
N A:GLY895 4.4 27.8 1.0
CA A:GLY895 4.5 27.8 1.0
O2G A:ATP1462 4.6 10.2 1.0
O2A A:ATP1462 4.6 23.2 1.0
O2B A:ATP1462 4.6 21.9 1.0
O3A A:ATP1462 4.8 21.4 1.0
O A:ASP893 4.8 23.8 1.0
CE A:LYS896 4.8 39.2 1.0
C A:ASP893 4.9 23.9 1.0
CA A:ASP893 4.9 23.0 1.0
PA A:ATP1462 5.0 23.9 1.0
O1A A:ATP1462 5.0 23.6 1.0
N A:LYS896 5.0 28.9 1.0

Magnesium binding site 3 out of 4 in 2aqx

Go back to Magnesium Binding Sites List in 2aqx
Magnesium binding site 3 out of 4 in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1600

b:33.5
occ:1.00
 OD2 B:ASP893 2.1 18.5 1.0
O3G B:ATP2462 2.4 16.1 1.0
O2A B:ATP2462 2.6 21.6 1.0
CG B:ASP893 3.0 23.1 1.0
OG B:SER876 3.2 23.6 1.0
O B:GLY874 3.3 26.9 1.0
CB B:ASP893 3.3 26.1 1.0
NZ B:LYS741 3.5 37.3 1.0
CE B:LYS741 3.5 36.3 1.0
PG B:ATP2462 3.9 20.2 1.0
CB B:SER876 3.9 22.7 1.0
PA B:ATP2462 4.0 19.6 1.0
OD1 B:ASP893 4.2 20.8 1.0
MG B:MG1601 4.2 20.2 1.0
C B:GLY874 4.4 26.0 1.0
OD2 B:ASP739 4.5 25.5 1.0
O3B B:ATP2462 4.6 16.5 1.0
O1B B:ATP2462 4.6 16.2 1.0
O1G B:ATP2462 4.6 16.1 1.0
O1A B:ATP2462 4.6 16.9 1.0
C B:SER875 4.6 23.5 1.0
N B:SER876 4.6 23.9 1.0
OE2 B:GLU810 4.7 44.8 1.0
OD1 B:ASP739 4.7 32.0 1.0
CA B:SER875 4.8 24.0 1.0
CA B:ASP893 4.8 26.9 1.0
CA B:SER876 4.9 23.4 1.0
O2G B:ATP2462 4.9 19.4 1.0
CD B:LYS741 5.0 33.5 1.0
O3A B:ATP2462 5.0 19.2 1.0
O5' B:ATP2462 5.0 20.9 1.0

Magnesium binding site 4 out of 4 in 2aqx

Go back to Magnesium Binding Sites List in 2aqx
Magnesium binding site 4 out of 4 in the Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Crystal Structure of the Catalytic and Cam-Binding Domains of Inositol 1,4,5-Trisphosphate 3-Kinase B within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1601

b:20.2
occ:1.00
 O1G B:ATP2462 2.1 16.1 1.0
OD1 B:ASP893 2.2 20.8 1.0
O1B B:ATP2462 2.3 16.2 1.0
OD2 B:ASP893 2.4 18.5 1.0
CG B:ASP893 2.6 23.1 1.0
PG B:ATP2462 3.1 20.2 1.0
O3G B:ATP2462 3.3 16.1 1.0
PB B:ATP2462 3.5 16.6 1.0
O3B B:ATP2462 3.8 16.5 1.0
CB B:ASP893 4.0 26.1 1.0
NZ B:LYS686 4.1 23.9 1.0
O B:GLY874 4.1 26.9 1.0
MG B:MG1600 4.2 33.5 1.0
O2G B:ATP2462 4.4 19.4 1.0
O2A B:ATP2462 4.4 21.6 1.0
N B:GLY895 4.5 29.7 1.0
O2B B:ATP2462 4.5 19.5 1.0
O3A B:ATP2462 4.6 19.2 1.0
CA B:GLY895 4.6 31.5 1.0
O1A B:ATP2462 4.7 16.9 1.0
PA B:ATP2462 4.7 19.6 1.0
CA B:ASP893 4.7 26.9 1.0
NZ B:LYS741 4.8 37.3 1.0
C B:ASP893 4.8 27.7 1.0

Reference:

P.P.Chamberlain, M.L.Sandberg, K.Sauer, M.P.Cooke, S.A.Lesley, G.Spraggon. Structural Insights Into Enzyme Regulation For Inositol 1,4,5-Trisphosphate 3-Kinase B Biochemistry V. 44 14486 2005.
ISSN: ISSN 0006-2960
PubMed: 16262249
DOI: 10.1021/BI051256Q
Page generated: Tue Aug 13 21:35:26 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy