Magnesium in PDB 2as5: Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna.

The structure of Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna., PDB code: 2as5 was solved by Y.Wu, J.C.Stroud, M.Borde, D.L.Bates, L.Guo, A.Han, A.Rao, L.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	65.455, 157.447, 67.666, 90.00, 118.67, 90.00
R / Rfree (%)	23.8 / 28.7

The binding sites of Magnesium atom in the Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna. (pdb code 2as5). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna., PDB code: 2as5:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna. within 5.0Å range: probe atom residue distance (Å) B Occ F:Mg201 b:59.1 occ:1.00 O F:PHE562 2.5 54.2 1.0 O F:SER557 2.5 64.4 1.0 O F:HIS559 2.8 64.7 1.0 O F:LEU556 3.1 53.3 1.0 C F:SER557 3.3 62.5 1.0 CA F:SER557 3.6 61.1 1.0 C F:PHE562 3.7 55.1 1.0 C F:HIS559 3.7 61.9 1.0 C F:LEU556 4.0 52.8 1.0 CA F:LYS560 4.2 67.8 1.0 N F:SER557 4.3 57.1 1.0 N F:LYS560 4.3 66.2 1.0 CB F:PHE562 4.4 47.2 1.0 CZ3 F:TRP573 4.4 28.1 1.0 N F:LEU558 4.4 62.2 1.0 N F:HIS559 4.4 61.3 1.0 CA F:PHE562 4.4 55.0 1.0 N F:PHE562 4.6 62.8 1.0 C F:LEU558 4.6 62.7 1.0 C F:LYS560 4.6 69.2 1.0 CA F:HIS559 4.7 60.9 1.0 N F:VAL563 4.7 56.4 1.0 O F:LYS560 4.7 67.6 1.0 O F:LEU558 4.8 60.1 1.0 CA F:VAL563 4.9 57.1 1.0 CB F:SER557 4.9 61.5 1.0 OG F:SER557 5.0 73.8 1.0 CH2 F:TRP573 5.0 27.3 1.0 CA F:LEU558 5.0 62.2 1.0

Magnesium binding site 2 out of 2 in the Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna.


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of the Dna Binding Domains of Nfat and FOXP2 Bound Specifically to Dna. within 5.0Å range: probe atom residue distance (Å) B Occ G:Mg202 b:56.4 occ:1.00 O G:PHE562 2.4 42.2 1.0 O G:SER557 2.6 61.0 1.0 O G:HIS559 2.6 65.2 1.0 O G:LEU556 2.9 45.0 1.0 C G:SER557 3.4 58.5 1.0 C G:PHE562 3.5 43.4 1.0 C G:HIS559 3.6 64.7 1.0 CA G:SER557 3.7 55.1 1.0 C G:LEU556 3.8 44.5 1.0 CB G:PHE562 4.1 43.6 1.0 CA G:LYS560 4.1 69.7 1.0 N G:SER557 4.2 49.5 1.0 CA G:PHE562 4.2 47.3 1.0 N G:LYS560 4.3 67.3 1.0 CZ3 G:TRP573 4.3 26.5 1.0 N G:PHE562 4.3 52.8 1.0 N G:HIS559 4.3 64.7 1.0 O G:LYS560 4.4 67.0 1.0 C G:LYS560 4.5 68.0 1.0 N G:LEU558 4.5 61.9 1.0 CA G:HIS559 4.6 64.3 1.0 C G:LEU558 4.6 65.1 1.0 N G:VAL563 4.6 41.1 1.0 CA G:VAL563 4.8 42.4 1.0 CH2 G:TRP573 4.9 28.8 1.0 O G:LEU558 5.0 65.4 1.0

Y.Wu, M.Borde, V.Heissmeyer, M.Feuerer, A.D.Lapan, J.C.Stroud, D.L.Bates, L.Guo, A.Han, S.F.Ziegler, D.Mathis, C.Benoist, L.Chen, A.Rao. FOXP3 Controls Regulatory T Cell Function Through Cooperation with Nfat. Cell(Cambridge,Mass.) V. 126 375 2006.
ISSN: ISSN 0092-8674
PubMed: 16873067
DOI: 10.1016/J.CELL.2006.05.042